Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin

Masashi Kanayama, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, Mari L. Shinohara

Research output: Contribution to journalArticle

Abstract

The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regulation of apoptosis. Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis. Our study suggests previously unknown detrimental roles for two OPN isoforms in causing the imbalance of leukocyte populations.

Original languageEnglish (US)
Pages (from-to)973-984
Number of pages12
JournalNature Immunology
Volume18
Issue number9
DOIs
StatePublished - Aug 22 2017

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Kanayama, M., Xu, S., Danzaki, K., Gibson, J. R., Inoue, M., Gregory, S. G., & Shinohara, M. L. (2017). Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nature Immunology, 18(9), 973-984. https://doi.org/10.1038/ni.3791