Sizing up the future of microRNA analysis

Abraham J. Qavi, Jared T. Kindt, Ryan C. Bailey

Research output: Contribution to journalReview articlepeer-review

Abstract

In less than 20 years, our appreciation for micro- RNA molecules (miRNAs) has grown from an original, curious observation in worms to their current status as incredibly important global regulators of gene expression that play key roles in many transformative biological processes. As our understanding of these small, noncoding transcripts continues to evolve, new approaches for their analysis are emerging. In this critical review we describe recent improvements to classical methods of detection as well as innovative new technologies that are poised to help shape the future landscape of miRNA analysis.

Original languageEnglish (US)
Pages (from-to)2535-2549
Number of pages15
JournalAnalytical and bioanalytical chemistry
Volume398
Issue number6
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • Bioanalytical methods
  • Bioassays
  • Biosensors
  • Nucleic acids (DNA | RNA)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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