Site-specific attachment of proteins onto a 3D DNA tetrahedron through backbone-modified phosphorothioate DNA

Ngo Yin Wong; Chuan Zhang; Li Huey Tan; Yi Lu

doi:10.1002/smll.201100140

Site-specific attachment of proteins onto a 3D DNA tetrahedron through backbone-modified phosphorothioate DNA

Ngo Yin Wong, Chuan Zhang, Li Huey Tan, Yi Lu

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Phosphorothioate-modified DNA and short bifunctional linkers are used to attach proteins to a DNA tetrahedron. Precise control of the position of and distance between protein modifications is achieved. This technique is simple, can be adapted to other DNA nanostructures, exhibits high yields, and the modification can be programmably placed within the structure.

Original language	English (US)
Pages (from-to)	1427-1430
Number of pages	4
Journal	Small
Volume	7
Issue number	10
DOIs	https://doi.org/10.1002/smll.201100140
State	Published - May 23 2011

Keywords

DNA structures
nanostructures
phosphorothioate
proteins
self-assembly

ASJC Scopus subject areas

Biomaterials
Engineering (miscellaneous)
Biotechnology
General Medicine

Online availability

10.1002/smll.201100140

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AU - Zhang, Chuan

AU - Tan, Li Huey

AU - Lu, Yi

PY - 2011/5/23

Y1 - 2011/5/23

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AB - Phosphorothioate-modified DNA and short bifunctional linkers are used to attach proteins to a DNA tetrahedron. Precise control of the position of and distance between protein modifications is achieved. This technique is simple, can be adapted to other DNA nanostructures, exhibits high yields, and the modification can be programmably placed within the structure.

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KW - nanostructures

KW - phosphorothioate

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KW - self-assembly

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Site-specific attachment of proteins onto a 3D DNA tetrahedron through backbone-modified phosphorothioate DNA

Abstract

Keywords

ASJC Scopus subject areas

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