Sirtuin 1 Deacetylase. A Key Regulator of Hepatic Lipid Metabolism.

Jongsook Kim Kemper, Sung E. Choi, Dong Hyun Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Obesity is a serious medical problem worldwide and disruption of metabolic/energy homeostasis plays a pivotal role in this global epidemic. In obese people, fatty liver (steatosis) develops, which increases the risk for diabetes, cardiovascular disease, and even, liver cancer. Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that functions as a key metabolic/energy sensor and mediates homeostatic responses to nutrient availability. Accumulating evidence indicates that SIRT1 is a master regulator of the transcriptional networks that control hepatic lipid metabolism. During energy-deprived conditions, SIRT1 deacetylates and alters the expression and activities of key transcriptional regulators involved in hepatic lipogenesis, fatty acid β-oxidation, and cholesterol/bile acid metabolism. This review will discuss the latest advances in this field, focusing on beneficial roles of SIRT1 in hepatic lipid metabolism including its potential as a therapeutic target for treatment of steatosis and other obesity-related metabolic diseases.

Original languageEnglish (US)
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Pages385-404
Number of pages20
DOIs
StatePublished - 2013

Publication series

NameVitamins and Hormones
Volume91
ISSN (Print)0083-6729

Keywords

  • Fatty liver
  • Lipogenesis
  • Obesity
  • SIRT1
  • SREBP-1c
  • β-Oxidation

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

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  • Cite this

    Kemper, J. K., Choi, S. E., & Kim, D. H. (2013). Sirtuin 1 Deacetylase. A Key Regulator of Hepatic Lipid Metabolism. In Vitamins and Hormones (pp. 385-404). (Vitamins and Hormones; Vol. 91). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-407766-9.00016-X