@inbook{3919ef9c25c7421096cddb08c56f9ee6,
title = "Sirtuin 1 Deacetylase. A Key Regulator of Hepatic Lipid Metabolism.",
abstract = "Obesity is a serious medical problem worldwide and disruption of metabolic/energy homeostasis plays a pivotal role in this global epidemic. In obese people, fatty liver (steatosis) develops, which increases the risk for diabetes, cardiovascular disease, and even, liver cancer. Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that functions as a key metabolic/energy sensor and mediates homeostatic responses to nutrient availability. Accumulating evidence indicates that SIRT1 is a master regulator of the transcriptional networks that control hepatic lipid metabolism. During energy-deprived conditions, SIRT1 deacetylates and alters the expression and activities of key transcriptional regulators involved in hepatic lipogenesis, fatty acid β-oxidation, and cholesterol/bile acid metabolism. This review will discuss the latest advances in this field, focusing on beneficial roles of SIRT1 in hepatic lipid metabolism including its potential as a therapeutic target for treatment of steatosis and other obesity-related metabolic diseases.",
keywords = "Fatty liver, Lipogenesis, Obesity, SIRT1, SREBP-1c, β-Oxidation",
author = "Kemper, {Jongsook Kim} and Choi, {Sung E.} and Kim, {Dong Hyun}",
note = "Funding Information: We apologize to those authors whose original works were not discussed in this review due to space limitations. We thank Byron Kemper for critical reading of the manuscript. Research discussed from the authors{\textquoteright} laboratory was supported by grants, NIH DK062777, NIH DK095842, and a Basic Science Award from the American Diabetes Association.",
year = "2013",
doi = "10.1016/B978-0-12-407766-9.00016-X",
language = "English (US)",
series = "Vitamins and Hormones",
publisher = "Academic Press Inc.",
pages = "385--404",
booktitle = "Vitamins and Hormones",
address = "United States",
}