Single virus analysis by correlated optical spectroscopy and atomic force microscopy

Warren C.W. Chan, Shuming Nie

Research output: Contribution to journalConference articlepeer-review


Single adeno- and tobacco mosaic viruses have been studied by correlated fluorescence spectroscopy and tapping-mode atomic force microscopy. The size and shape of spatially isolated, fluorescently tagged viruses are measured on the nanometer scale, and the fluorescent labels in each virus are determined by wavelength-resolved spectroscopy. This work extends ultrasensitive measurement to the single-virus level and is expected to have applications in studying gene therapy vectors and virus-cell interactions.

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Scanning and Force Microscopies for Biomedical Applications - San Jose, CA, USA
Duration: Jan 24 1999Jan 25 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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