Single-step DNA immobilization on antifouling self-assembled monolayers covalently bound to silicon (111)

Till Böcking, Kristopher A. Kilian, Katharina Gaus, J. Justin Gooding

Research output: Contribution to journalArticlepeer-review

Abstract

Hydrosilylation of alkenes with epoxide-terminated tri(ethylene oxide) moieties on Si-H surfaces yields homogeneous monolayers for the efficient coupling of biomolecules. The wetting properties of the epoxide-functionalized surface allow for the spotting of solutions of biomolecules, making the surface amenable to microarraying. Immobilization of thiolated DNA was achieved in a single step to fabricate biorecognition interfaces showing the hybridization of complementary DNA at low concentrations and negligible binding of noncomplementary DNA.

Original languageEnglish (US)
Pages (from-to)3494-3496
Number of pages3
JournalLangmuir
Volume22
Issue number8
DOIs
StatePublished - Apr 11 2006

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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