Abstract
Single molecule studies allow for the direct observation of polymer dynamics in dilute and concentrated solutions, thereby revealing polymer chain conformations and molecular sub-populations that may be obscured in ensemble-level measurements. Over the past two decades, researchers have used DNA as a model system to study polymer dynamics at the molecular level. The vast majority of studies have focused on linear DNA molecules; however, researchers have recently begun to study polymers with complex topologies and architectures at the single molecule level. Here, we explore recent work in single polymer dynamics focused on topologically complex DNA, including knots, ring polymers, and branched polymers. Experimental, computational, and theoretical advances have enabled in-depth studies of topologically complex DNA, with recent efforts focused on complex molecular conformations, intermolecular interactions, and topology-dependent dynamics. In this article, we highlight recent work aimed at understanding the interplay between molecular-scale behavior and the emergent properties of polymeric materials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28-40 |
| Number of pages | 13 |
| Journal | Current Opinion in Colloid and Interface Science |
| Volume | 26 |
| DOIs | |
| State | Published - Dec 1 2016 |
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Keywords
- Architecture
- Branched polymers
- DNA
- Knots
- Polymer
- Rings
- Single molecule
- Topology
ASJC Scopus subject areas
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Polymers and Plastics
- Colloid and Surface Chemistry
Cite this
Single polymer dynamics of topologically complex DNA. / Mai, Danielle J.; Schroeder, Charles M.
In: Current Opinion in Colloid and Interface Science, Vol. 26, 01.12.2016, p. 28-40.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Single polymer dynamics of topologically complex DNA
AU - Mai, Danielle J.
AU - Schroeder, Charles M
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Single molecule studies allow for the direct observation of polymer dynamics in dilute and concentrated solutions, thereby revealing polymer chain conformations and molecular sub-populations that may be obscured in ensemble-level measurements. Over the past two decades, researchers have used DNA as a model system to study polymer dynamics at the molecular level. The vast majority of studies have focused on linear DNA molecules; however, researchers have recently begun to study polymers with complex topologies and architectures at the single molecule level. Here, we explore recent work in single polymer dynamics focused on topologically complex DNA, including knots, ring polymers, and branched polymers. Experimental, computational, and theoretical advances have enabled in-depth studies of topologically complex DNA, with recent efforts focused on complex molecular conformations, intermolecular interactions, and topology-dependent dynamics. In this article, we highlight recent work aimed at understanding the interplay between molecular-scale behavior and the emergent properties of polymeric materials.
AB - Single molecule studies allow for the direct observation of polymer dynamics in dilute and concentrated solutions, thereby revealing polymer chain conformations and molecular sub-populations that may be obscured in ensemble-level measurements. Over the past two decades, researchers have used DNA as a model system to study polymer dynamics at the molecular level. The vast majority of studies have focused on linear DNA molecules; however, researchers have recently begun to study polymers with complex topologies and architectures at the single molecule level. Here, we explore recent work in single polymer dynamics focused on topologically complex DNA, including knots, ring polymers, and branched polymers. Experimental, computational, and theoretical advances have enabled in-depth studies of topologically complex DNA, with recent efforts focused on complex molecular conformations, intermolecular interactions, and topology-dependent dynamics. In this article, we highlight recent work aimed at understanding the interplay between molecular-scale behavior and the emergent properties of polymeric materials.
KW - Architecture
KW - Branched polymers
KW - DNA
KW - Knots
KW - Polymer
KW - Rings
KW - Single molecule
KW - Topology
UR - http://www.scopus.com/inward/record.url?scp=84988699951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84988699951&partnerID=8YFLogxK
U2 - 10.1016/j.cocis.2016.08.003
DO - 10.1016/j.cocis.2016.08.003
M3 - Review article
AN - SCOPUS:84988699951
VL - 26
SP - 28
EP - 40
JO - Current Opinion in Colloid and Interface Science
JF - Current Opinion in Colloid and Interface Science
SN - 1359-0294
ER -