Abstract
We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single base pair difference, it may lead to a single molecule sensor of minute sequence differences of a target DNA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 496-500 |
| Number of pages | 5 |
| Journal | Nano letters |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2006 |
ASJC Scopus subject areas
- Bioengineering
- General Chemistry
- General Materials Science
- Condensed Matter Physics
- Mechanical Engineering