Single molecule mechanics of fibronectin type III domains: relating structure, function, and stability using steered molecular dynamics

David Craig, Andre Krammer, Klaus Schulten, Viola Vogel

Research output: Contribution to journalConference articlepeer-review

Abstract

The forced-unfolding pathways of four domains (Fn-III7, 8, 9, 10) were studied using steered molecular dynamics. The relative mechanical stability of these pathways were deduced. Two energy barriers separating the native state were found.

Original languageEnglish (US)
Pages (from-to)S-92
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering

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