Single-molecule imaging with quantum dots

Mohammad U. Zahid, Andrew M. Smith

Research output: Chapter in Book/Report/Conference proceedingChapter


Quantum dots (QDs) are a class of fluorescent nanocrystal with unique optical and electronic properties (Smith et al. 2008; Smith and Nie 2009a). Originally investigated as components for light-emitting devices, solar cells, and catalysts in the early 1980s, these particles were introduced in 1998 as optical tags for bioimaging and biological detection (Chan and Nie 1998; Bruchez et al. 1998). Over the ensuing 15 years, their most significant contribution to biomedicine has been in the field of single-molecule fluorescence microscopy, for which they have filled a major need for bright fluorescent probes with long-term photostability. These particles are now widely used for imaging the dynamics of individual molecules and the interactions between molecules in complex biological environments.

Original languageEnglish (US)
Title of host publicationOptical Nanoscopy and Novel Microscopy Techniques
PublisherCRC Press
Number of pages26
ISBN (Electronic)9781466586307
ISBN (Print)9781466586291
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Social Sciences(all)
  • Physics and Astronomy(all)
  • Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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