Herein we report on the single-molecule analysis of a conserved DNA quadruplex element found in the transcriptional activation site of the promoter of the proto- oncogene c-kit. We demonstrate that the c-kit quadruplex motif is able to fold into nonduplex states within a natural extended DNA duplex. There are apparent differences in putative quadruplex structures, and the K+ dependence on quadruplex formation, that appear to result when studying this quadruplex motif in natural duplex, as opposed to the single-stranded form.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the American Chemical Society|
|State||Published - Jun 20 2007|
ASJC Scopus subject areas
- Colloid and Surface Chemistry