@article{c1dd234bc2e14ffa902ba58610c14156,
title = "Single-Cell Studies of Phage λ: Hidden Treasures under Occam's Rug",
abstract = "Studies over more than half a century have resulted in what some consider a complete narrative for the life cycle of bacteriophage λ. However, this narrative is only complete within the limited resolution offered by the traditional genetic and biochemical approaches that were used to create it. A recent series of studies performed at the single-cell and single-phage levels has revealed a wealth of previously unknown features. By pointing to many open questions, these new studies highlight the limitations of our current understanding of λ, but they also initiate the process of forming a more detailed and quantitative narrative for the system.",
keywords = "Decision-making, Escherichia coli, Fluorescence microscopy, Lysis, Lysogeny, Noise, Phage lambda, Systems biology",
author = "Ido Golding",
note = "Funding Information: ACKNOWLEDGMENTS: I am grateful to the following members of my lab for providing unpublished results, for creating figures, and for giving feedback on the text: Sam Skinner, Louis McLane, Jing Zhang, Leonardo Sep{\'u}lveda, and Andrew Frink. Work in the Golding lab is supported by grants from the National Institutes of Health (R01 GM082837), the National Science Foundation (PHY 1147498, PHY 1430124, and PHY 1427654), the Welch Foundation (Q-1759), and the John S. Dunn Foundation (Collaborative Research Award). I gratefully acknowledge the computing resources provided by the Computational and Integrative Biomedical Research Center of Baylor College of Medicine. Publisher Copyright: {\textcopyright} Copyright 2016 by Annual Reviews. All rights reserved.",
year = "2016",
month = sep,
day = "29",
doi = "10.1146/annurev-virology-110615-042127",
language = "English (US)",
volume = "3",
pages = "453--472",
journal = "Annual Review of Virology",
issn = "2327-056X",
publisher = "Annual Reviews, inc.",
}