Simultaneous QSM and metabolic imaging of the brain using SPICE

Xi Peng, Fan Lam, Yudu Li, Bryan Clifford, Zhi-Pei Liang

Research output: Contribution to journalArticle

Abstract

Purpose: To map brain metabolites and tissue magnetic susceptibility simultaneously using a single three-dimensional 1H-MRSI acquisition without water suppression. Methods: The proposed technique builds on a subspace imaging method called spectroscopic imaging by exploiting spatiospectral correlation (SPICE), which enables ultrashort echo time (TE)/short pulse repetition time (TR) acquisitions for 1H-MRSI without water suppression. This data acquisition scheme simultaneously captures both the spectral information of brain metabolites and the phase information of the water signals that is directly related to tissue magnetic susceptibility variations. In extending this scheme for simultaneous QSM and metabolic imaging, we increase k-space coverage by using dual density sparse sampling and ramp sampling to achieve spatial resolution often required by QSM, while maintaining a reasonable signal-to-noise ratio (SNR) for the spatiospectral data used for metabolite mapping. In data processing, we obtain high-quality QSM from the unsuppressed water signals by taking advantage of the larger number of echoes acquired and any available anatomical priors; metabolite spatiospectral distributions are reconstructed using a union-of-subspaces model. Results: In vivo experimental results demonstrate that the proposed method can produce susceptibility maps at a resolution higher than 1.8 × 1.8 × 2.4 mm3 along with metabolite spatiospectral distributions at a nominal spatial resolution of 2.4 × 2.4 × 2.4 mm3 from a single 7-min MRSI scan. The estimated susceptibility values are consistent with those obtained using the conventional QSM method with 3D multi-echo gradient echo acquisitions. Conclusion: This article reports a new capability for simultaneous susceptibility mapping and metabolic imaging of the brain from a single 1H-MRSI scan, which has potential for a wide range of applications. Magn Reson Med 79:13–21, 2018.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalMagnetic Resonance in Medicine
Volume79
Issue number1
DOIs
StatePublished - Jan 2018

Fingerprint

Neuroimaging
Water
Architectural Accessibility
Brain
Signal-To-Noise Ratio

Keywords

  • SPICE
  • partial separability
  • quantitative susceptibility mapping
  • spectroscopic imaging
  • subspace modeling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Simultaneous QSM and metabolic imaging of the brain using SPICE. / Peng, Xi; Lam, Fan; Li, Yudu; Clifford, Bryan; Liang, Zhi-Pei.

In: Magnetic Resonance in Medicine, Vol. 79, No. 1, 01.2018, p. 13-21.

Research output: Contribution to journalArticle

Peng, Xi ; Lam, Fan ; Li, Yudu ; Clifford, Bryan ; Liang, Zhi-Pei. / Simultaneous QSM and metabolic imaging of the brain using SPICE. In: Magnetic Resonance in Medicine. 2018 ; Vol. 79, No. 1. pp. 13-21.
@article{601240f91b3d46439f86c21cdcf96611,
title = "Simultaneous QSM and metabolic imaging of the brain using SPICE",
abstract = "Purpose: To map brain metabolites and tissue magnetic susceptibility simultaneously using a single three-dimensional 1H-MRSI acquisition without water suppression. Methods: The proposed technique builds on a subspace imaging method called spectroscopic imaging by exploiting spatiospectral correlation (SPICE), which enables ultrashort echo time (TE)/short pulse repetition time (TR) acquisitions for 1H-MRSI without water suppression. This data acquisition scheme simultaneously captures both the spectral information of brain metabolites and the phase information of the water signals that is directly related to tissue magnetic susceptibility variations. In extending this scheme for simultaneous QSM and metabolic imaging, we increase k-space coverage by using dual density sparse sampling and ramp sampling to achieve spatial resolution often required by QSM, while maintaining a reasonable signal-to-noise ratio (SNR) for the spatiospectral data used for metabolite mapping. In data processing, we obtain high-quality QSM from the unsuppressed water signals by taking advantage of the larger number of echoes acquired and any available anatomical priors; metabolite spatiospectral distributions are reconstructed using a union-of-subspaces model. Results: In vivo experimental results demonstrate that the proposed method can produce susceptibility maps at a resolution higher than 1.8 × 1.8 × 2.4 mm3 along with metabolite spatiospectral distributions at a nominal spatial resolution of 2.4 × 2.4 × 2.4 mm3 from a single 7-min MRSI scan. The estimated susceptibility values are consistent with those obtained using the conventional QSM method with 3D multi-echo gradient echo acquisitions. Conclusion: This article reports a new capability for simultaneous susceptibility mapping and metabolic imaging of the brain from a single 1H-MRSI scan, which has potential for a wide range of applications. Magn Reson Med 79:13–21, 2018.",
keywords = "SPICE, partial separability, quantitative susceptibility mapping, spectroscopic imaging, subspace modeling",
author = "Xi Peng and Fan Lam and Yudu Li and Bryan Clifford and Zhi-Pei Liang",
year = "2018",
month = "1",
doi = "10.1002/mrm.26972",
language = "English (US)",
volume = "79",
pages = "13--21",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Simultaneous QSM and metabolic imaging of the brain using SPICE

AU - Peng, Xi

AU - Lam, Fan

AU - Li, Yudu

AU - Clifford, Bryan

AU - Liang, Zhi-Pei

PY - 2018/1

Y1 - 2018/1

N2 - Purpose: To map brain metabolites and tissue magnetic susceptibility simultaneously using a single three-dimensional 1H-MRSI acquisition without water suppression. Methods: The proposed technique builds on a subspace imaging method called spectroscopic imaging by exploiting spatiospectral correlation (SPICE), which enables ultrashort echo time (TE)/short pulse repetition time (TR) acquisitions for 1H-MRSI without water suppression. This data acquisition scheme simultaneously captures both the spectral information of brain metabolites and the phase information of the water signals that is directly related to tissue magnetic susceptibility variations. In extending this scheme for simultaneous QSM and metabolic imaging, we increase k-space coverage by using dual density sparse sampling and ramp sampling to achieve spatial resolution often required by QSM, while maintaining a reasonable signal-to-noise ratio (SNR) for the spatiospectral data used for metabolite mapping. In data processing, we obtain high-quality QSM from the unsuppressed water signals by taking advantage of the larger number of echoes acquired and any available anatomical priors; metabolite spatiospectral distributions are reconstructed using a union-of-subspaces model. Results: In vivo experimental results demonstrate that the proposed method can produce susceptibility maps at a resolution higher than 1.8 × 1.8 × 2.4 mm3 along with metabolite spatiospectral distributions at a nominal spatial resolution of 2.4 × 2.4 × 2.4 mm3 from a single 7-min MRSI scan. The estimated susceptibility values are consistent with those obtained using the conventional QSM method with 3D multi-echo gradient echo acquisitions. Conclusion: This article reports a new capability for simultaneous susceptibility mapping and metabolic imaging of the brain from a single 1H-MRSI scan, which has potential for a wide range of applications. Magn Reson Med 79:13–21, 2018.

AB - Purpose: To map brain metabolites and tissue magnetic susceptibility simultaneously using a single three-dimensional 1H-MRSI acquisition without water suppression. Methods: The proposed technique builds on a subspace imaging method called spectroscopic imaging by exploiting spatiospectral correlation (SPICE), which enables ultrashort echo time (TE)/short pulse repetition time (TR) acquisitions for 1H-MRSI without water suppression. This data acquisition scheme simultaneously captures both the spectral information of brain metabolites and the phase information of the water signals that is directly related to tissue magnetic susceptibility variations. In extending this scheme for simultaneous QSM and metabolic imaging, we increase k-space coverage by using dual density sparse sampling and ramp sampling to achieve spatial resolution often required by QSM, while maintaining a reasonable signal-to-noise ratio (SNR) for the spatiospectral data used for metabolite mapping. In data processing, we obtain high-quality QSM from the unsuppressed water signals by taking advantage of the larger number of echoes acquired and any available anatomical priors; metabolite spatiospectral distributions are reconstructed using a union-of-subspaces model. Results: In vivo experimental results demonstrate that the proposed method can produce susceptibility maps at a resolution higher than 1.8 × 1.8 × 2.4 mm3 along with metabolite spatiospectral distributions at a nominal spatial resolution of 2.4 × 2.4 × 2.4 mm3 from a single 7-min MRSI scan. The estimated susceptibility values are consistent with those obtained using the conventional QSM method with 3D multi-echo gradient echo acquisitions. Conclusion: This article reports a new capability for simultaneous susceptibility mapping and metabolic imaging of the brain from a single 1H-MRSI scan, which has potential for a wide range of applications. Magn Reson Med 79:13–21, 2018.

KW - SPICE

KW - partial separability

KW - quantitative susceptibility mapping

KW - spectroscopic imaging

KW - subspace modeling

UR - http://www.scopus.com/inward/record.url?scp=85038075052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038075052&partnerID=8YFLogxK

U2 - 10.1002/mrm.26972

DO - 10.1002/mrm.26972

M3 - Article

C2 - 29067730

AN - SCOPUS:85038075052

VL - 79

SP - 13

EP - 21

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 1

ER -