Abstract
Membrane compartments of manifold shapes are found in cells, often sculpted by cellular proteins. In particular, proteins of the BAR domain superfamily participate in membrane-sculpting processes in vivo and reshape also in vitro low-curvature membrane liposomes into high-curvature tubes and vesicles. Here we show by means of computer simulations totaling over 1 millisecond, how lattices involving parallel rows of amphiphysin N-BAR domains sculpt flat membranes into tubes. A highly detailed, dynamic picture of the 100-microsecond formation of membrane tubes by lattices of N-BAR domains is obtained. Lattice types inducing a wide range of membrane curvatures, with radii approximately 15-100 nm, are explored. The results suggest that multiple lattice types are viable for efficient membrane bending.
Original language | English (US) |
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Pages (from-to) | 882-892 |
Number of pages | 11 |
Journal | Structure |
Volume | 17 |
Issue number | 6 |
DOIs | |
State | Published - Jun 10 2009 |
Externally published | Yes |
Keywords
- CELLBIO
- PROTEINS
ASJC Scopus subject areas
- Molecular Biology
- Structural Biology