Simulation of ion conduction in the ompF porin channel using BioMOCA

Kyu II Lee, Trudy A. Van Der Straaten, Gulzar A. Kathawala, Young June Park, Umberto Ravaioli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The BioMOCA simulations of K+ and Cl- transport through the ompF porin channel, were analyzed. OmpF porin is a highly charged trimeric protein channel found in the outer membrane of the E.coli bacterium. Mutations and drift-diffusion (DD) simulations both indicate that the charge distribution in the constriction region plays an important role in the conductance properties of the channel. The results show that BioMOCA simulator can be used to simulate this line of enquiry using a map for the permanent charge distribution to investigate the conduction properties of ompF.

Original languageEnglish (US)
Title of host publication2004 10th International Workshop on Computational Electronics, IEEE IWCE-10 2004, Abstracts
Pages131-132
Number of pages2
StatePublished - Dec 1 2004
Event2004 10th International Workshop on Computational Electronics: The Field of Computational Electronics - Looking Back and Looking Ahead, IEEE IWCE-10 2004, Abstracts - West Lafayette, IN, United States
Duration: Oct 24 2004Oct 27 2004

Publication series

Name2004 10th International Workshop on Computational Electronics, IEEE IWCE-10 2004, Abstracts

Other

Other2004 10th International Workshop on Computational Electronics: The Field of Computational Electronics - Looking Back and Looking Ahead, IEEE IWCE-10 2004, Abstracts
CountryUnited States
CityWest Lafayette, IN
Period10/24/0410/27/04

ASJC Scopus subject areas

  • Engineering(all)

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    Lee, K. II., Van Der Straaten, T. A., Kathawala, G. A., Park, Y. J., & Ravaioli, U. (2004). Simulation of ion conduction in the ompF porin channel using BioMOCA. In 2004 10th International Workshop on Computational Electronics, IEEE IWCE-10 2004, Abstracts (pp. 131-132). (2004 10th International Workshop on Computational Electronics, IEEE IWCE-10 2004, Abstracts).