Simulation frameworks for large-scale brain systems

In this paper we review the relatively recent effort on the part of cognitive neuroscientists to use computational neural modeling in conjunction with functional brain imaging, especially the hemodynamic-based methods such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). The reason why such a review is in a book on brain connectivity is that many of these efforts involve neural models that consist of multiple interacting neuronal populations, and thus issues associated with connectivity are often implicitly or explicitly addressed.