Abstract
This Minireview provides an overview on the development of silyl ketene imines and their recent applications in catalytic, enantioselective reactions. The unique structure of the ketene imine allows a diverse range of reactivity patterns and provides solutions to existing challenges in the enantioselective construction of quaternary stereogenic carbon centers and cross-benzoin adducts. A variety of reactions for which silyl ketene imines have been applied are presented with an overall goal of inspiring new uses for these underutilized nucleophiles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9980-9992 |
| Number of pages | 13 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 40 |
| DOIs | |
| State | Published - Oct 1 2012 |
Keywords
- asymmetric catalysis
- cyanides
- silanes
- synthetic methods
- umpolung
ASJC Scopus subject areas
- Catalysis
- General Chemistry