Silyl ketene imines: Highly versatile nucleophiles for catalytic, asymmetric synthesis

Scott E. Denmark, Tyler W. Wilson

Research output: Contribution to journalReview article

Abstract

This Minireview provides an overview on the development of silyl ketene imines and their recent applications in catalytic, enantioselective reactions. The unique structure of the ketene imine allows a diverse range of reactivity patterns and provides solutions to existing challenges in the enantioselective construction of quaternary stereogenic carbon centers and cross-benzoin adducts. A variety of reactions for which silyl ketene imines have been applied are presented with an overall goal of inspiring new uses for these underutilized nucleophiles.

Original languageEnglish (US)
Pages (from-to)9980-9992
Number of pages13
JournalAngewandte Chemie - International Edition
Volume51
Issue number40
DOIs
StatePublished - Oct 1 2012

Keywords

  • asymmetric catalysis
  • cyanides
  • silanes
  • synthetic methods
  • umpolung

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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