Abstract
The silicon-directed Nazarov cyclization was shown to proceed with good to excellent stereoselectivity in cyclohexenyl systems bearing a variety of ring substituents. In all cases the trans family of isomers predominated, and cis ring-fused products were formed exclusively. The potential for stereocontrol by increasing the bulk of silicon substituents was limited for five-membered rings and good for six-membered rings. Phenylsilanes were found to participate in cyclization.
Original language | English (US) |
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Pages (from-to) | 2821-2829 |
Number of pages | 9 |
Journal | Tetrahedron |
Volume | 42 |
Issue number | 11 |
DOIs | |
State | Published - 1986 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry