Silicon-based mesoporous photonic crystals: Towards single cell optical biosensors

Kristopher A. Kilian, Astrid Magenau, Till Böcking, Katharina Gaus, Michael Gal, J. Justin Gooding

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mesoporous silicon (PSi) photonic crystals have attracted interest as biosensing transducers owing to their high quality optics and sensitivity in optical characteristics to changes in refractive index. We describe progress our group has made derivatizing PSi towards devices for biology and medicine. PSi rugate filters display a high reflectivity resonant line in the reflectance spectrum. As an example for biosensing, immobilization of peptides and biopolymers within the PSi is demonstrated for detecting protease enzymes. Secretion of matrix metalloproteases from live cells was detected as a blue shift in the photonic resonance within hours, demonstrating the promise of this biosensor.

Original languageEnglish (US)
Title of host publicationBiosensing II
DOIs
StatePublished - Dec 1 2009
EventBiosensing II - San Diego, CA, United States
Duration: Aug 4 2009Aug 6 2009

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume7397
ISSN (Print)0277-786X

Other

OtherBiosensing II
Country/TerritoryUnited States
CitySan Diego, CA
Period8/4/098/6/09

Keywords

  • Porous silicon
  • biosensor
  • cell culture
  • photonic crystal
  • protease

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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