Silencing: the establishment and inheritance of stable, repressed transcription states

David H. Rivier; Jasper Rine

doi:10.1016/S0959-437X(05)80286-2

Silencing: the establishment and inheritance of stable, repressed transcription states

David H. Rivier
, Jasper Rine

Research output: Contribution to journal › Article › peer-review

Abstract

Silencing refers to a particular type of transcriptional repression characterized by the formation of a genetically heritable, repressed transcriptional state. Examples of silencing include position-effect variegation, X-chromosome inactivation, and the repression of the silent mating-type gene loci in yeast. Recent discoveries suggest that silencing in yeast, like silencing in larger eukaryotes, results from a particular chromatin structure that defines a chromosomal domain. In addition, a chromosomal origin of DNA replication is required for silencing in yeast, suggesting that DNA replication plays a role in forming functional chromosomal domains.

Original language	English (US)
Pages (from-to)	286-292
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/S0959-437X(05)80286-2
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/S0959-437X(05)80286-2

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abstract = "Silencing refers to a particular type of transcriptional repression characterized by the formation of a genetically heritable, repressed transcriptional state. Examples of silencing include position-effect variegation, X-chromosome inactivation, and the repression of the silent mating-type gene loci in yeast. Recent discoveries suggest that silencing in yeast, like silencing in larger eukaryotes, results from a particular chromatin structure that defines a chromosomal domain. In addition, a chromosomal origin of DNA replication is required for silencing in yeast, suggesting that DNA replication plays a role in forming functional chromosomal domains.",

author = "Rivier, \{David H.\} and Jasper Rine",

note = "We thank L Pillus and P baurenson for extensive discussion and for helpful comments on the manuscript. Work from the authors' lab is supported by the National Institutes of Health grant GM31105 and by a postdoctoral fellowship from the California Division of the American Cancer Society (D Rivier) and 13\}' HIEHS training grant ES07075 (D Rivier).",

year = "1992",

doi = "10.1016/S0959-437X(05)80286-2",

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AU - Rine, Jasper

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PY - 1992

Y1 - 1992

N2 - Silencing refers to a particular type of transcriptional repression characterized by the formation of a genetically heritable, repressed transcriptional state. Examples of silencing include position-effect variegation, X-chromosome inactivation, and the repression of the silent mating-type gene loci in yeast. Recent discoveries suggest that silencing in yeast, like silencing in larger eukaryotes, results from a particular chromatin structure that defines a chromosomal domain. In addition, a chromosomal origin of DNA replication is required for silencing in yeast, suggesting that DNA replication plays a role in forming functional chromosomal domains.

AB - Silencing refers to a particular type of transcriptional repression characterized by the formation of a genetically heritable, repressed transcriptional state. Examples of silencing include position-effect variegation, X-chromosome inactivation, and the repression of the silent mating-type gene loci in yeast. Recent discoveries suggest that silencing in yeast, like silencing in larger eukaryotes, results from a particular chromatin structure that defines a chromosomal domain. In addition, a chromosomal origin of DNA replication is required for silencing in yeast, suggesting that DNA replication plays a role in forming functional chromosomal domains.

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Silencing: the establishment and inheritance of stable, repressed transcription states

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