TY - JOUR
T1 - Silencing
T2 - the establishment and inheritance of stable, repressed transcription states
AU - Rivier, David H.
AU - Rine, Jasper
N1 - Funding Information:
We thank L Pillus and P baurenson for extensive discussion and for helpful comments on the manuscript. Work from the authors' lab is supported by the National Institutes of Health grant GM31105 and by a postdoctoral fellowship from the California Division of the American Cancer Society (D Rivier) and 13}' HIEHS training grant ES07075 (D Rivier).
PY - 1992
Y1 - 1992
N2 - Silencing refers to a particular type of transcriptional repression characterized by the formation of a genetically heritable, repressed transcriptional state. Examples of silencing include position-effect variegation, X-chromosome inactivation, and the repression of the silent mating-type gene loci in yeast. Recent discoveries suggest that silencing in yeast, like silencing in larger eukaryotes, results from a particular chromatin structure that defines a chromosomal domain. In addition, a chromosomal origin of DNA replication is required for silencing in yeast, suggesting that DNA replication plays a role in forming functional chromosomal domains.
AB - Silencing refers to a particular type of transcriptional repression characterized by the formation of a genetically heritable, repressed transcriptional state. Examples of silencing include position-effect variegation, X-chromosome inactivation, and the repression of the silent mating-type gene loci in yeast. Recent discoveries suggest that silencing in yeast, like silencing in larger eukaryotes, results from a particular chromatin structure that defines a chromosomal domain. In addition, a chromosomal origin of DNA replication is required for silencing in yeast, suggesting that DNA replication plays a role in forming functional chromosomal domains.
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U2 - 10.1016/S0959-437X(05)80286-2
DO - 10.1016/S0959-437X(05)80286-2
M3 - Article
C2 - 1638123
AN - SCOPUS:0026845839
SN - 0959-437X
VL - 2
SP - 286
EP - 292
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 2
ER -