Silencing: the establishment and inheritance of stable, repressed transcription states

David H. Rivier, Jasper Rine

Research output: Contribution to journalArticlepeer-review


Silencing refers to a particular type of transcriptional repression characterized by the formation of a genetically heritable, repressed transcriptional state. Examples of silencing include position-effect variegation, X-chromosome inactivation, and the repression of the silent mating-type gene loci in yeast. Recent discoveries suggest that silencing in yeast, like silencing in larger eukaryotes, results from a particular chromatin structure that defines a chromosomal domain. In addition, a chromosomal origin of DNA replication is required for silencing in yeast, suggesting that DNA replication plays a role in forming functional chromosomal domains.

Original languageEnglish (US)
Pages (from-to)286-292
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number2
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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