@article{28bb5ad57d104032b9f3bc32c4dc6f58,
title = "Signaling pathways in spermatogonial stem cells and their disruption by toxicants",
abstract = "Spermatogenesis is a complex biological process that is particularly sensitive to environmental insults such as chemicals and physical stressors. Exposure to specific chemicals has been shown to inhibit fertility through a negative impact on germ cell proliferation and differentiation that can lower sperm count. In addition, toxicants might produce DNA damages that could have negative consequences on the development of the offspring. This review describes spermatogonial stem cell development in the testis, signaling pathways that are crucial for self-renewal, and possible target molecules for environmental toxicants such as phthalate esters and nanoparticles.",
keywords = "Nanoparticles, Phthalates, Signaling pathways, Spermatogonial stem cells",
author = "Benjamin Lucas and Christopher Fields and Hofmann, {Marie Claude}",
note = "Funding Information: of Science and Technology and the Department of Ocean Development, Government of India, for providing funds to procure the ocean-bottom magnetometers and to the Marine Wing, Geological Survey of India (GSI) for providing the RV Samudra Manthan. Support given by Mr. B. R. J. Rao and Mr. B. K. Saha and the scientists on board SM 86 is gratefully acknowledged. The scientists from the Indian Institute of Geomagnetism are grateful to Profs. P. Weidelt and U. Schmucker for fruitful suggestions and guidance during this work. One of the authors (B.B.) expresses his appreciation to Prof. B. N. P. Agarwal and Dr. R. K. Shaw for providing software support. He also thanks the Director-General, Geological Survey of India, for his kind permission to publish this paper.",
year = "2009",
month = mar,
doi = "10.1002/bdrc.20145",
language = "English (US)",
volume = "87",
pages = "35--42",
journal = "Birth Defects Research Part C - Embryo Today: Reviews",
issn = "1542-975X",
publisher = "Wiley-Liss Inc.",
number = "1",
}