Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing

Laith Q. Al-Mawsawi, Nicholas C. Wu, Justin De La Cruz, Vivian Cai Shi, Ting Ting Wu, Eric S. Daar, Martha J. Lewis, Otto O. Yang, Ren Sun

Research output: Contribution to journalArticlepeer-review

Abstract

Acute HIV-1 infection is characterized by the rapid generation of highly diverse genetic variants to adapt to the new host environment. Understanding the dynamics of viral genetic variation at this stage of infection is critical for vaccine design efforts and early drug treatment. Here, using a high-resolution deep sequencing approach targeting the HIV-1 gag region, we reveal very early immune pressure with dramatic subpopulation shifts in a single acutely infected participant providing further insight into the genetic dynamics of acute HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)806-811
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume30
Issue number8
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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