Short chain fatty acid (SCFA) supplementation of total parenteral nutrition (TPN) reduces skeletal muscle catabolism following intestinal resection

K. A. Tappenden, M. I. McBurnev

Research output: Contribution to journalArticlepeer-review

Abstract

A primary metabolic response following surgery is accelerated skeletal muscle catabolism and a translocation of amino acids to visceral organs. To examine the effect of SCFA on postsurgical muscle proteolysis, 48 male Sprague-Dawley rats (249±10g) underwent an 80% jejunoileal resection and jugular catheterization. Rats were randomly assigned to receive standard TPN (TPN) or an isoenergetic, isonitrogenous TPN supplemented with SCFA (TPN+SCFA) containing 36, 15 and 9 mmol/L of acetate, proprionate, and butyrate respectively. Diets were infused for either 3 or 7 days to provide 1 7 g nitrogen/(kgday) and 196 nonprotein kcals/(kgday) Nitrogen balance did not differ among groups. Seven days following surgery, urinary 3-methyihistidine excretion was significantly higher (P<0.05) in the TPN group when compared to the TPN+SCFA group (TPN, 72±5 nmol/mL vs TPN+SCFA, 55±5 nmol/mL). Plasma glutamine concentrations were higher (PO.02) in the TPN+SCFA group both 3 and 7 days following surgery (TPN-3, 630±41; TPN-7 604±40; TPN+SCFA-3, 672±39; TPN+SCFA-7, 764±43 nmol/mL). These results indicate that SCFA supplementation of TPN increases plasma glutamine concentrations and may reduce skeletal muscle catabolism following massive small bowel resection.

Original languageEnglish (US)
Pages (from-to)A207
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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