Shell cross-linked nanoparticles designed to target angiogenic blood vessels via α vβ 3 receptor-ligand interactions

Dipanjan Pan, Jeffrey L. Turner, Karen L. Wooley

Research output: Contribution to journalArticle

Abstract

The design, synthesis, and characterization of a novel polymeric nanostructured material bearing surface-attached integrin antagonists are demonstrated. The covalent coupling of a complex and biologically active small molecule to a well-defined nanostructured material combines the elegance of synthetic organic chemistry with the state-of-the-art polymer chemistry. This unique material offers potential in targeting to tumor neovasculature and delivery of diagnostic and therapeutic agents.

Original languageEnglish (US)
Pages (from-to)7109-7115
Number of pages7
JournalMacromolecules
Volume37
Issue number19
DOIs
StatePublished - Sep 21 2004
Externally publishedYes

ASJC Scopus subject areas

  • Materials Chemistry

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