Abstract
The design, synthesis, and characterization of a novel polymeric nanostructured material bearing surface-attached integrin antagonists are demonstrated. The covalent coupling of a complex and biologically active small molecule to a well-defined nanostructured material combines the elegance of synthetic organic chemistry with the state-of-the-art polymer chemistry. This unique material offers potential in targeting to tumor neovasculature and delivery of diagnostic and therapeutic agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7109-7115 |
| Number of pages | 7 |
| Journal | Macromolecules |
| Volume | 37 |
| Issue number | 19 |
| DOIs | |
| State | Published - Sep 21 2004 |
| Externally published | Yes |
ASJC Scopus subject areas
- Materials Chemistry
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Cite this
Pan, D., Turner, J. L., & Wooley, K. L. (2004). Shell cross-linked nanoparticles designed to target angiogenic blood vessels via α vβ 3 receptor-ligand interactions. Macromolecules, 37(19), 7109-7115. https://doi.org/10.1021/ma048824e