TY - JOUR
T1 - Shared and derived features of cellular diversity in the human cerebral cortex
AU - Miller, Daniel J.
AU - Bhaduri, Aparna
AU - Sestan, Nenad
AU - Kriegstein, Arnold
N1 - Funding Information:
We apologize to the colleagues whose work in the field could not be cited because of space restrictions. This work was supported, in part, by grants from the National Institutes of Health and the Simons Foundation .
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/6
Y1 - 2019/6
N2 - The cerebral cortex is the hallmark of the mammalian nervous system, and its large size and cellular diversity in humans support our most sophisticated cognitive abilities. Although the basic cellular organization of the cortex is conserved across mammals, cells have diversified during evolution. An increasingly integrated taxonomy of cell types, especially with the advent of single-cell transcriptomic data, has revealed an unprecedented variety of human cortical cell subtypes. Here, we broadly review the cellular composition and diversity of the mammalian brain, and how progenitor pools generate cell subtypes during development. We then discuss human cortical cells that are distinct from rodent cells, as well as the challenges and advantages of using model systems to study human cell types in health and disease.
AB - The cerebral cortex is the hallmark of the mammalian nervous system, and its large size and cellular diversity in humans support our most sophisticated cognitive abilities. Although the basic cellular organization of the cortex is conserved across mammals, cells have diversified during evolution. An increasingly integrated taxonomy of cell types, especially with the advent of single-cell transcriptomic data, has revealed an unprecedented variety of human cortical cell subtypes. Here, we broadly review the cellular composition and diversity of the mammalian brain, and how progenitor pools generate cell subtypes during development. We then discuss human cortical cells that are distinct from rodent cells, as well as the challenges and advantages of using model systems to study human cell types in health and disease.
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U2 - 10.1016/j.conb.2018.12.005
DO - 10.1016/j.conb.2018.12.005
M3 - Review article
C2 - 30677551
AN - SCOPUS:85060196972
SN - 0959-4388
VL - 56
SP - 117
EP - 124
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -