Shaping the nuclear action of NF-κB

Lin Feng Chen, Warner C. Greene

Research output: Contribution to journalReview articlepeer-review


The NF-κB/REL family of transcription factors pivotally control the inflammatory and immune responses, as well as other genetic programmes that are central to cell growth and survival. The cytoplasmic regulation of NF-κB is well characterized and, recently, significant progress has been made in understanding how its nuclear action is regulated. Post-translational modification of the NF-κB subunits as well as histones surrounding the NF-κB target genes has a key role in this regulation. Here, we review the important advances that constitute this new and exciting chapter in NF-κB biology.

Original languageEnglish (US)
Pages (from-to)392-401
Number of pages10
JournalNature Reviews Molecular Cell Biology
Issue number5
StatePublished - May 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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