TY - JOUR
T1 - Shaping Molecular Landscapes
T2 - Recent Advances, Opportunities, and Challenges in Dearomatization
AU - Huck, Christopher J.
AU - Sarlah, David
N1 - Funding Information:
Financial support for this work was provided by the University of Illinois and the NIH National Institute of General Medical Sciences (R01 GM122891). Amgen, Eli Lilly, and Bristol-Myers Squibb are also acknowledged for unrestricted research support. C.J.H. would like to acknowledge support from a National Science Foundation graduate research fellowship, as well as a Robert C. and Carolyn J. Springborn Fellowship. C.J.H. and D.S. designed the figures and wrote the manuscript.
Funding Information:
Financial support for this work was provided by the University of Illinois and the NIH National Institute of General Medical Sciences ( R01 GM122891 ). Amgen , Eli Lilly , and Bristol-Myers Squibb are also acknowledged for unrestricted research support. C.J.H. would like to acknowledge support from a National Science Foundation graduate research fellowship, as well as a Robert C. and Carolyn J. Springborn Fellowship.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/7/9
Y1 - 2020/7/9
N2 - Dearomatization is a fundamental chemical transformation, and it underlies some of the most efficient tactics for generating three-dimensional complexity from basic two-dimensional precursors. The dearomative toolbox, once restricted to only a handful of reactions, has begun to grow more sophisticated as novel methods are added, introducing more functionality under milder conditions and with more control over chemo-, regio-, and stereoselectivity than ever before. Over the past two decades, major developments in dearomative processes have bolstered significant total-synthesis endeavors and greatly expanded the scope and complexity of chemical building blocks accessible from feedstock arenes. In this Perspective, we highlight some of the recent advances and key challenges that remain in this vibrant area of organic chemistry.
AB - Dearomatization is a fundamental chemical transformation, and it underlies some of the most efficient tactics for generating three-dimensional complexity from basic two-dimensional precursors. The dearomative toolbox, once restricted to only a handful of reactions, has begun to grow more sophisticated as novel methods are added, introducing more functionality under milder conditions and with more control over chemo-, regio-, and stereoselectivity than ever before. Over the past two decades, major developments in dearomative processes have bolstered significant total-synthesis endeavors and greatly expanded the scope and complexity of chemical building blocks accessible from feedstock arenes. In this Perspective, we highlight some of the recent advances and key challenges that remain in this vibrant area of organic chemistry.
KW - SDG3: Good health and well-being
KW - SDG9: Industry, innovation, and infrastructure
KW - n/a
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U2 - 10.1016/j.chempr.2020.06.015
DO - 10.1016/j.chempr.2020.06.015
M3 - Review article
C2 - 32715154
AN - SCOPUS:85087428858
SN - 2451-9294
VL - 6
SP - 1589
EP - 1603
JO - Chem
JF - Chem
IS - 7
ER -