Shape-constrained multi-atlas segmentation of spleen in CT

Zhoubing Xu, Bo Li, Swetasudha Panda, Andrew J. Asman, Kristen L. Merkle, Peter L. Shanahan, Richard G. Abramson, Bennett A. Landman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Spleen segmentation on clinically acquired CT data is a challenging problem given the complicity and variability of abdominal anatomy. Multi-atlas segmentation is a potential method for robust estimation of spleen segmentations, but can be negatively impacted by registration errors. Although labeled atlases explicitly capture information related to feasible organ shapes, multi-atlas methods have largely used this information implicitly through registration. We propose to integrate a level set shape model into the traditional label fusion framework to create a shape-constrained multi-atlas segmentation framework. Briefly, we (1) adapt two alternative atlas-to-target registrations to obtain the loose bounds on the inner and outer boundaries of the spleen shape, (2) project the fusion estimate to registered shape models, and (3) convert the projected shape into shape priors. With the constraint of the shape prior, our proposed method offers a statistically significant improvement in spleen labeling accuracy with an increase in DSC by 0.06, a decrease in symmetric mean surface distance by 4.01 mm, and a decrease in symmetric Hausdorff surface distance by 23.21 mm when compared to a locally weighted vote (LWV) method.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2014
Subtitle of host publicationImage Processing
PublisherSPIE
ISBN (Print)9780819498274
DOIs
StatePublished - 2014
Externally publishedYes
EventMedical Imaging 2014: Image Processing - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9034
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2014: Image Processing
CountryUnited States
CitySan Diego, CA
Period2/16/142/18/14

Keywords

  • Implicit shape model
  • Multi-atlas segmentation
  • PCA
  • Spleen segmentation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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