Sex differences in ventricular–vascular coupling following endurance training

A. D. Lane, H. Yan, S. M. Ranadive, R. M. Kappus, P. Sun, M. D. Cook, I. Harvey, J. Woods, K. Wilund, B. Fernhall

Research output: Contribution to journalArticle

Abstract

Introduction: Ventricular and vascular coupling is defined as the ratio of arterial elastance (Ea) to ventricular elastance (Elv) and describes the interaction between the heart and arterial system. There are sex differences in both arterial and ventricular function in response to both acute exercise and aerobic exercise training.

Purpose: To examine the effects of aerobic exercise training on elastances and the coupling ratio in young adult men and women. We hypothesized a reduction in the coupling ratio in both sexes due to a decrease in Ea that would be more pronounced in men and an increase in Elv that would be larger in women.

Methods: Fifty-three healthy, young adults completed the study. Central pulse wave velocity and heart volumes were measured before and after an 8-week aerobic training intervention. Elastances were calculated as Ea = end-systolic pressure/stroke volume and Elv = end-systolic pressure/end-systolic volume and indexed to body surface area.

Results: After the intervention, women augmented indexed and un-indexed Elv from 2.09 ± 0.61 to 2.52 ± 0.80 mmHg/ml, p < 0.05, and reduced the coupling ratio from 0.72 ± 18 to 0.62 ± 15, p < 0.05, while men maintained their pre-training ratio (from 0.66 ± 0.20 to 0.74 ± 0.21, p > 0.05). Women also reduced end-systolic pressure (from 91 ± 10 to 87 ± 10 mmHg), and both groups reduced central pulse wave velocity (from 6.0 ± 1.0 to 5.6 ± 0.6 m/s, p < 0.05).

Conclusion: We conclude that after 8 weeks of aerobic training, only women reduced their coupling ratio due to an increase in Elv. This suggests that aerobic exercise training elicits sex-dependent changes in the coupling ratio in young, healthy individuals.

Original languageEnglish (US)
Pages (from-to)2597-2606
Number of pages10
JournalEuropean Journal of Applied Physiology
Volume114
Issue number12
DOIs
StatePublished - Jan 1 2014

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Sex Characteristics
Exercise
Pulse Wave Analysis
Blood Pressure
Young Adult
Cardiac Volume
Ventricular Function
Body Surface Area
Stroke Volume
Blood Vessels

Keywords

  • End-systolic pressure
  • Exercise
  • Systolic performance

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

Cite this

Lane, A. D., Yan, H., Ranadive, S. M., Kappus, R. M., Sun, P., Cook, M. D., ... Fernhall, B. (2014). Sex differences in ventricular–vascular coupling following endurance training. European Journal of Applied Physiology, 114(12), 2597-2606. https://doi.org/10.1007/s00421-014-2981-z

Sex differences in ventricular–vascular coupling following endurance training. / Lane, A. D.; Yan, H.; Ranadive, S. M.; Kappus, R. M.; Sun, P.; Cook, M. D.; Harvey, I.; Woods, J.; Wilund, K.; Fernhall, B.

In: European Journal of Applied Physiology, Vol. 114, No. 12, 01.01.2014, p. 2597-2606.

Research output: Contribution to journalArticle

Lane, AD, Yan, H, Ranadive, SM, Kappus, RM, Sun, P, Cook, MD, Harvey, I, Woods, J, Wilund, K & Fernhall, B 2014, 'Sex differences in ventricular–vascular coupling following endurance training', European Journal of Applied Physiology, vol. 114, no. 12, pp. 2597-2606. https://doi.org/10.1007/s00421-014-2981-z
Lane, A. D. ; Yan, H. ; Ranadive, S. M. ; Kappus, R. M. ; Sun, P. ; Cook, M. D. ; Harvey, I. ; Woods, J. ; Wilund, K. ; Fernhall, B. / Sex differences in ventricular–vascular coupling following endurance training. In: European Journal of Applied Physiology. 2014 ; Vol. 114, No. 12. pp. 2597-2606.
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AU - Harvey, I.

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