Sex differences and estropausal phase effects on water maze performance in aged rats

Stacey G. Warren, Janice M. Juraska

Research output: Contribution to journalArticlepeer-review

Abstract

An age-related decline in memory has been reported in male rats; however, there are few studies that have addressed these changes in aged female rats. In young female rats, hormonal cycles influence behavior. By the age of 22 months most female rats have not had regular hormonal cycles for at least 9 months. In the current study we examined how the hormonal status (persistent estrus and pseudo-pregnant) of the aged (22-24 months) female rat (Long Evans) influenced performance on a spatial version of the Morris water maze and compared this to aged male rats. Aged females in persistent estrus showed better performance on the water maze than both aged females that were pseudopregnant and aged males. Thus, postestropausal hormonal status may influence the course of aging in females. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)229-240
Number of pages12
JournalNeurobiology of Learning and Memory
Volume74
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Aging
  • Estropause
  • Persistent estrus
  • Rat
  • Sex difference
  • Water maze

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Sex differences and estropausal phase effects on water maze performance in aged rats'. Together they form a unique fingerprint.

Cite this