Seven new microcystins possessing two L-glutamic acid units, isolated from Anabaena sp. strain 186

Michio Namikoshi, Moucun Yuan, Kaarina Sivonen, Wayne W. Carmichael, Kenneth L. Rinehart, Leo Rouhiainen, Furong Sun, Scott Brittain, Akira Otsuki

Research output: Contribution to journalArticlepeer-review

Abstract

Electrospray ionization mass spectrometry has been applied to the structure assignment of seven new microcystins (1-7), obtained from cultured Anabaena sp. strain 186. The seven new microcystins contain the dehydroalanine (Dha) or L-Ser unit instead of the N-methyldehydroalanine unit and the L-Glu and/or its δ-methyl ester [E(OMe)] units at the two variable L-amino acid units, and the structures were assigned as [Dha7]microcystin- E(OMe)E(OMe) (1), [D-Asp3,Dha7]microcystin-E(OMe)E(OMe) (2), [L- Ser7]microcystin-E(OMe)E(OMe) (3), [D-Asp3,L-Ser7]microcystin-E(OMe)E(OMe) (4), [Dha7]microcystin-EE(OMe) (5), [D-Asp3,Dha7]microcystin-EE(OMe) (6), and [L-Ser7]microcystin-EE(OMe) (7). These microcystins are the first examples containing dicarboxylic amino acids at the two variable L-amino acid units in microcystins.

Original languageEnglish (US)
Pages (from-to)143-149
Number of pages7
JournalChemical Research in Toxicology
Volume11
Issue number2
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Toxicology

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