TY - JOUR
T1 - Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students
T2 - The UP-AMIGOS Cohort Study
AU - Vazquez-Vidal, Itzel
AU - Voruganti, V. Saroja
AU - Hannon, Bridget A.
AU - Andrade, Flavia Cristina Drumond
AU - Aradillas-García, Celia
AU - Nakamura, Manabu T.
AU - Terán-García, Margarita
N1 - Funding Information:
This study was funded by the University of Illinois at Urbana- Champaign Research Board grant No. 09070 (to F.C.D.A.); Center for Health and Aging (to F.C.D.A.); ACES Office of Research FIRE grant (to M.T.-G. and Wiley), and the USDA National Institute of Food and Agriculture, Hatch Projects No. ILLU-968-312 and No. ILLU 971-368 (to M.T.-G.). Funding was also provided by the Universidad Autónoma de San Luis Potosí, The Hormones Laboratory at the School of Medicine, the Clinical Biochemistry Laboratory at the Chemical Sciences School, and the UASLP University Health Center under agreement support C09-PIFI-030606 (to C.A.-G.). B.A.H. and M.T.-G. are supported by USDA National Institute of Food (NIFA) and Agriculture Research Initiative Competitive Grant No. 2015-68001-23248. M.T.-G. also recognizes her support from USDA NIFA Hatch Project ILLU-793-327. I.V.V. was supported by CONACYT-Mexico (2010-2013) and a fellowship from the American Association University Women (AAUW, 2013-2014) during her doctoral degree.
Funding Information:
This study was funded by the University of Illinois at Urbana-Champaign Research Board grant No. 09070 (to F.C.D.A.); Center for Health and Aging (to F.C.D.A.); ACES Office of Research FIRE grant (to M.T.-G. and Wiley), and the USDA National Institute of Food and Agriculture, Hatch Projects No. ILLU-968-312 and No. ILLU 971-368 (to M.T.-G.). Funding was also provided by the Uni-versidad Autónoma de San Luis Potosí, The Hormones Laboratory at the School of Medicine, the Clinical Biochemistry Laboratory at the Chemical Sciences School, and the UASLP University Health Center under agreement support C09-PIFI-030606 (to C.A.-G.). B.A.H. and M.T.-G. are supported by USDA National Institute of Food (NIFA) and Agriculture Research Initiative Competitive Grant No. 2015-68001-23248. M.T.-G. also recognizes her support from USDA NIFA Hatch Project ILLU-793-327. I.V.V. was supported by CONACYT-Mexico (2010–2013) and a fellowship from the American Association University Women (AAUW, 2013–2014) during her doctoral degree.
Publisher Copyright:
© 2018 S. Karger AG, Basel.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Background: Recent genome-wide association studies in the Mexican population have identified several genetic loci associated with blood lipid levels in adults. However, studies focusing on the fatty acid desaturase (FADS) gene cluster have been understudied in this population, even though it seems associated with lipid profiles in other ethnicities. The aim of this study was to test associations between single nucleotide polymorphisms (SNPs) in the FADS cluster (rs174546, rs1535, rs174548, rs174550, rs174450, and rs174618) and serum lipid profiles in young Mexicans. Methods: Anthropometrics, serum lipid profiles, and FADS SNPs were measured in 998 subjects in the UP-AMIGOS cohort study. Genotype-phenotype (total cholesterol [TC], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and very-low-density lipoprotein [VLDL]) associations were assessed using PLINK adjusted for sex, age, and body mass index (BMI). Results: Among 6 FADS SNPs, we found that carriers of the C-allele of the FADS1-rs174546 showed a significant association with lower TG concentrations (β = -12.6 mg/dL, p = 0.009) and lower VLDL concentrations (β = -2.52 mg/dL, p = 0.005). We found that rs174546, rs1535, and rs174550 were in high linkage disequilibrium (r2 > 0.80). There were no significant associations between rs174550, rs174548, and rs174618 and lipid profiles. Conclusion: A genetic variant in the FADS1 (rs174546) gene is a major contributor of plasma TG and VLDL concentrations in healthy young Mexicans.
AB - Background: Recent genome-wide association studies in the Mexican population have identified several genetic loci associated with blood lipid levels in adults. However, studies focusing on the fatty acid desaturase (FADS) gene cluster have been understudied in this population, even though it seems associated with lipid profiles in other ethnicities. The aim of this study was to test associations between single nucleotide polymorphisms (SNPs) in the FADS cluster (rs174546, rs1535, rs174548, rs174550, rs174450, and rs174618) and serum lipid profiles in young Mexicans. Methods: Anthropometrics, serum lipid profiles, and FADS SNPs were measured in 998 subjects in the UP-AMIGOS cohort study. Genotype-phenotype (total cholesterol [TC], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and very-low-density lipoprotein [VLDL]) associations were assessed using PLINK adjusted for sex, age, and body mass index (BMI). Results: Among 6 FADS SNPs, we found that carriers of the C-allele of the FADS1-rs174546 showed a significant association with lower TG concentrations (β = -12.6 mg/dL, p = 0.009) and lower VLDL concentrations (β = -2.52 mg/dL, p = 0.005). We found that rs174546, rs1535, and rs174550 were in high linkage disequilibrium (r2 > 0.80). There were no significant associations between rs174550, rs174548, and rs174618 and lipid profiles. Conclusion: A genetic variant in the FADS1 (rs174546) gene is a major contributor of plasma TG and VLDL concentrations in healthy young Mexicans.
KW - Blood lipid
KW - FADS genotype
KW - Young healthy Mexicans
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U2 - 10.1159/000488085
DO - 10.1159/000488085
M3 - Article
C2 - 29847832
AN - SCOPUS:85054529603
SN - 2504-3161
VL - 11
SP - 40
EP - 48
JO - Lifestyle Genomics
JF - Lifestyle Genomics
IS - 1
ER -