TY - JOUR
T1 - Serum concentrations of lipid-soluble vitamins in dogs with exocrine pancreatic insufficiency treated with pancreatic enzymes
AU - Barko, Patrick C.
AU - Williams, David A.
N1 - Funding Information:
This article was completed at the University of Illinois College of Veterinary Medicine in Urbana, IL. This project was supported by gifts from Stan and Gail Peskin, The Gatens family, and Epi4dogs Inc. These data were presented in preliminary form at the 2017 meeting of the Comparative Gastroenterology Society in Kauai, HI and an abstract was published in the proceedings of the 27th European College of Veterinary Internal Medicine Congress.
Funding Information:
information Epi4Dogs Inc.: 501c3 Non-Profit Public Charity. Farmville, VA 23901, Grant/Award Number: n/a; The Gatens Family, Grant/Award Number: n/a; The Peskin Family, Grant/Award Number: n/aThis article was completed at the University of Illinois College of Veterinary Medicine in Urbana, IL. This project was supported by gifts from Stan and Gail Peskin, The Gatens family, and Epi4dogs Inc. These data were presented in preliminary form at the 2017 meeting of the Comparative Gastroenterology Society in Kauai, HI and an abstract was published in the proceedings of the 27th European College of Veterinary Internal Medicine Congress. Authors declare no off-label use of antimicrobials. This study utilized only residual serum samples from an unrelated study of canine EPI. Samples collection protocols for this study were reviewed and approved by the University of Illinois IACUC (protocol ID number 14284).
Publisher Copyright:
© 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background: In humans, exocrine pancreatic insufficiency (EPI) is associated with deficiencies in lipid-soluble vitamins. Little is reported regarding lipid-soluble vitamin status in dogs with EPI. Hypothesis/Objectives: Compare serum concentrations of retinol, 25-hydrocholecalciferol (25OHD), and α-tocopherol among dogs with EPI, those with subclinical EPI (sEPI), and healthy dogs. Detect associations between serum concentrations of lipid-soluble vitamins and residual clinical signs in treated dogs with EPI and sEPI. Animals: Twenty dogs with EPI and five dogs with sEPI receiving pancreatic enzyme replacement therapy. Ten healthy dogs sampled before and after 10 days of pancreatic enzyme supplementation. Methods: Case-control study. Serum retinol and α-tocopherol concentrations were measured by high-performance liquid chromatography. Serum 25OHD concentrations were measured by radioimmunoassay. Results: Serum retinol concentration was significantly lower in dogs with EPI (median, 490 ng/mL; range, 322-990 ng/mL) and serum α-tocopherol concentration was significantly lower in dogs with EPI (median, 11.51 μg/L; range, 4.8-27.1 μg/L) and sEPI (median, 12.66 μg/L; range, 10.21-21.03 μg/L) compared with healthy dogs (median, 1203 ng/mL; range, 637-1768 ng/mL and median, 43.54 μg/L; range, 34.26-53.97 μg/L, respectively). Dogs with weight loss had significantly lower 25OHD (mean, 243.50 nmol/L; standard deviation [SD], 3.54 nmol/L) than dogs with stable weight (314.0 nmol/L; SD, 138.38 nmol/L). Conclusions and Clinical Importance: Altered homeostasis of lipid-soluble vitamins is present in dogs with EPI and sEPI, despite enzyme replacement therapy. Additional studies are needed to determine the clinical relevance of these findings and the therapeutic potential of lipid-soluble vitamin supplementation in dogs with EPI and sEPI.
AB - Background: In humans, exocrine pancreatic insufficiency (EPI) is associated with deficiencies in lipid-soluble vitamins. Little is reported regarding lipid-soluble vitamin status in dogs with EPI. Hypothesis/Objectives: Compare serum concentrations of retinol, 25-hydrocholecalciferol (25OHD), and α-tocopherol among dogs with EPI, those with subclinical EPI (sEPI), and healthy dogs. Detect associations between serum concentrations of lipid-soluble vitamins and residual clinical signs in treated dogs with EPI and sEPI. Animals: Twenty dogs with EPI and five dogs with sEPI receiving pancreatic enzyme replacement therapy. Ten healthy dogs sampled before and after 10 days of pancreatic enzyme supplementation. Methods: Case-control study. Serum retinol and α-tocopherol concentrations were measured by high-performance liquid chromatography. Serum 25OHD concentrations were measured by radioimmunoassay. Results: Serum retinol concentration was significantly lower in dogs with EPI (median, 490 ng/mL; range, 322-990 ng/mL) and serum α-tocopherol concentration was significantly lower in dogs with EPI (median, 11.51 μg/L; range, 4.8-27.1 μg/L) and sEPI (median, 12.66 μg/L; range, 10.21-21.03 μg/L) compared with healthy dogs (median, 1203 ng/mL; range, 637-1768 ng/mL and median, 43.54 μg/L; range, 34.26-53.97 μg/L, respectively). Dogs with weight loss had significantly lower 25OHD (mean, 243.50 nmol/L; standard deviation [SD], 3.54 nmol/L) than dogs with stable weight (314.0 nmol/L; SD, 138.38 nmol/L). Conclusions and Clinical Importance: Altered homeostasis of lipid-soluble vitamins is present in dogs with EPI and sEPI, despite enzyme replacement therapy. Additional studies are needed to determine the clinical relevance of these findings and the therapeutic potential of lipid-soluble vitamin supplementation in dogs with EPI and sEPI.
KW - malabsorption
KW - retinol
KW - tocopherol
KW - vitamin A
KW - vitamin D
KW - vitamin E
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U2 - 10.1111/jvim.15292
DO - 10.1111/jvim.15292
M3 - Article
C2 - 30133868
AN - SCOPUS:85052381821
SN - 0891-6640
VL - 32
SP - 1600
EP - 1608
JO - Journal of veterinary internal medicine
JF - Journal of veterinary internal medicine
IS - 5
ER -