Serum alhpa 1-acid glycoprotein concentrations in healthy and tumor-bearing cats

K. A. Selting, G. K. Ogilvie, S. E. Lana, M. J. Fettman, K. L. Mitchener, R. A. Hansen, K. L. Richardson, J. A. Walton, M. A. Scherk

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to evaluate alpha 1-acid glycoprotein (AGP) concentrations in tumor-bearing and healthy cats. The hypothesis of the present study was that AGP concentrations would be significantly increased in tumor-bearing cats. Serum from 51 healthy and 97 tumor-bearing, client-owned cats was harvested at the time of presentation and stored at -80 degrees C until assayed. Cats with measurable, histologically confirmed malignancies, and healthy cats of similar ages were included. Serum was assayed for AGP concentration by using a radial immunodiffusion method. AGP concentrations were significantly (P = .0051) higher in tumor-bearing (763 +/- 595 microg/mL; mean +/- SD) when compared to healthy cats (501 +/- 377 microg/mL; mean +/- SD). Of the tumor-bearing cats, 35 had carcinomas, 33 had sarcomas, and 26 had discrete, round cell tumors. AGP concentrations were 645 +/- 62 microg/mL, 660 +/- 540 microg/mL, and 967 +/- 860 microg/mL, respectively, and there were no significant differences among the groups.

Original languageEnglish (US)
Pages (from-to)503-506
Number of pages4
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Issue number5
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • General Veterinary


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