Serial monoxenous transmission of toxoplasma gondii in cats

H. O. Awobode, A. J. Paul, H. Sengoku-Graham, R. W. Clem, N. E. Mateus-Pinilla, M. M. McAllister

Research output: Contribution to journalArticlepeer-review


Oral administration of Toxoplasma gondii oocysts to cats (i.e., monoxenous transmission) typically induces patent infections in fewer than half of test subjects. In the present study, oral administration of T. gondii oocysts to 5 kittens induced a patent infection in 2 of them, but only 1 kitten shed enough oocysts to enable further study. Those monoxenously-produced oocysts were administered to another kitten, which produced a second generation of monoxenous oocysts, and then those were used to induce a third generation of monoxenous oocysts. These results provide a rationale to develop a strain of T. gondii that has efficient direct transmission. The isolate of T. gondii that was able to be passaged in this manner has been designated the Dubey strain and cultured tachyzoites have been donated to a repository.

Original languageEnglish (US)
Pages (from-to)1122-1124
Number of pages3
JournalJournal of Parasitology
Issue number6
StatePublished - Dec 2013

ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics


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