Serial monoxenous transmission of toxoplasma gondii in cats

H. O. Awobode, Allan Paul, H. Sengoku-Graham, R. W. Clem, Nohra E Mateus-Pinilla, M. M. McAllister

Research output: Contribution to journalArticle

Abstract

Oral administration of Toxoplasma gondii oocysts to cats (i.e., monoxenous transmission) typically induces patent infections in fewer than half of test subjects. In the present study, oral administration of T. gondii oocysts to 5 kittens induced a patent infection in 2 of them, but only 1 kitten shed enough oocysts to enable further study. Those monoxenously-produced oocysts were administered to another kitten, which produced a second generation of monoxenous oocysts, and then those were used to induce a third generation of monoxenous oocysts. These results provide a rationale to develop a strain of T. gondii that has efficient direct transmission. The isolate of T. gondii that was able to be passaged in this manner has been designated the Dubey strain and cultured tachyzoites have been donated to a repository.

Original languageEnglish (US)
Pages (from-to)1122-1124
Number of pages3
JournalJournal of Parasitology
Volume99
Issue number6
DOIs
StatePublished - Dec 1 2013

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Oocysts
Toxoplasma
Toxoplasma gondii
oocysts
Cats
cats
kittens
repository
patents
oral administration
Oral Administration
tachyzoites
Infection
infection
patent
test
testing

ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Awobode, H. O., Paul, A., Sengoku-Graham, H., Clem, R. W., Mateus-Pinilla, N. E., & McAllister, M. M. (2013). Serial monoxenous transmission of toxoplasma gondii in cats. Journal of Parasitology, 99(6), 1122-1124. https://doi.org/10.1645/13-280.1

Serial monoxenous transmission of toxoplasma gondii in cats. / Awobode, H. O.; Paul, Allan; Sengoku-Graham, H.; Clem, R. W.; Mateus-Pinilla, Nohra E; McAllister, M. M.

In: Journal of Parasitology, Vol. 99, No. 6, 01.12.2013, p. 1122-1124.

Research output: Contribution to journalArticle

Awobode, HO, Paul, A, Sengoku-Graham, H, Clem, RW, Mateus-Pinilla, NE & McAllister, MM 2013, 'Serial monoxenous transmission of toxoplasma gondii in cats', Journal of Parasitology, vol. 99, no. 6, pp. 1122-1124. https://doi.org/10.1645/13-280.1
Awobode HO, Paul A, Sengoku-Graham H, Clem RW, Mateus-Pinilla NE, McAllister MM. Serial monoxenous transmission of toxoplasma gondii in cats. Journal of Parasitology. 2013 Dec 1;99(6):1122-1124. https://doi.org/10.1645/13-280.1
Awobode, H. O. ; Paul, Allan ; Sengoku-Graham, H. ; Clem, R. W. ; Mateus-Pinilla, Nohra E ; McAllister, M. M. / Serial monoxenous transmission of toxoplasma gondii in cats. In: Journal of Parasitology. 2013 ; Vol. 99, No. 6. pp. 1122-1124.
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