Sequestration of biomolecules for controlled delivery in mineralized collagen scaffolds

Aleczandria Tiffany, Brendan A Harley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose. Craniomaxillofacial (CMF) bone injuries display complex injury patterns and poor prognosis. Difficulties associated with donor site morbidity (autologous grafts) as well as high donor-to donor variability (allogenic grafts) motivate efforts to generate tissue engineering solutions. Efforts in our lab have recently developed a mineralized collagen-GAG scaffold that promotes robust stem cell attachment, proliferation, osteogenic differentiation, and mineral deposition in the absence of exogenous osteogenic factors1. However, these materials face significant challenges for translation to clinical-scale, critically-sized bone defects, notably the need to improve implant osseointegration (cell recruitment, osteogenesis, angiogenesis). Bone healing is a complex process with growth factor presentation varying temporally and spatially2,3, motivating efforts to recapitulate elements of this complex biomolecular landscape. Here we describe a sequestration strategy to incorporate and retain growth factors within our mineralized collagen constructs.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Tiffany, A., & Harley, B. A. (2019). Sequestration of biomolecules for controlled delivery in mineralized collagen scaffolds. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.