Sequence-specific binding of m-phenylene ethynylene foldamers to a piperazinium dihydrochloride salt

Kazuki Goto, Jeffrey S. Moore

Research output: Contribution to journalArticlepeer-review

Abstract

(Chemical Equation Presented) Binding properties of a series of isomeric m-phenylene ethynylene oligomers containing short amide sequences to a piperazinium dihydrochloride salt were investigated by using circular dichroism (CD) measurements. Although these isomeric oligomers exhibited similar helical conformations, high affinity was observed only for one oligomer. This behavior is presumably controlled by the orientation of amino groups of the amide sequence and the folded conformation of the oligomer.

Original languageEnglish (US)
Pages (from-to)1683-1686
Number of pages4
JournalOrganic Letters
Volume7
Issue number9
DOIs
StatePublished - Apr 28 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Sequence-specific binding of m-phenylene ethynylene foldamers to a piperazinium dihydrochloride salt'. Together they form a unique fingerprint.

Cite this