Sensitivity of peripheral membrane proteins to the membrane context

A case study of phosphatidylserine and the TIM proteins

Daniel Kerr, Gregory T. Tietjen, Zhiliang Gong, Emad Tajkhorshid, Erin J. Adams, Ka Yee C. Lee

Research output: Contribution to journalReview article

Abstract

There is a diverse class of peripheral membrane-binding proteins that specifically bind phosphatidylserine (PS), a lipid that signals apoptosis or cell fusion depending on the membrane context of its presentation. PS-receptors are specialized for particular PS-presenting pathways, indicating that they might be sensitive to the membrane context. In this review, we describe a combination of thermodynamic, structural, and computational techniques that can be used to investigate the mechanisms underlying this sensitivity. As an example, we focus on three PS-receptors of the T-cell Immunoglobulin and Mucin containing (TIM) protein family, which we have previously shown to differ in their sensitivity to PS surface density.

Original languageEnglish (US)
Pages (from-to)2126-2133
Number of pages8
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1860
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

T-cells
Phosphatidylserines
Mucins
Immunoglobulins
Membrane Proteins
Membranes
T-Lymphocytes
Proteins
Cell Fusion
Thermodynamics
Carrier Proteins
Fusion reactions
Apoptosis
Lipids
phosphatidylserine receptor

Keywords

  • Membrane composition sensitivity
  • PS recognition
  • Peripheral membrane proteins
  • Phosphatidylserine
  • TIM protein family

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

Sensitivity of peripheral membrane proteins to the membrane context : A case study of phosphatidylserine and the TIM proteins. / Kerr, Daniel; Tietjen, Gregory T.; Gong, Zhiliang; Tajkhorshid, Emad; Adams, Erin J.; Lee, Ka Yee C.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1860, No. 10, 01.10.2018, p. 2126-2133.

Research output: Contribution to journalReview article

Kerr, Daniel ; Tietjen, Gregory T. ; Gong, Zhiliang ; Tajkhorshid, Emad ; Adams, Erin J. ; Lee, Ka Yee C. / Sensitivity of peripheral membrane proteins to the membrane context : A case study of phosphatidylserine and the TIM proteins. In: Biochimica et Biophysica Acta - Biomembranes. 2018 ; Vol. 1860, No. 10. pp. 2126-2133.
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