TY - JOUR
T1 - Sensitivity of peripheral membrane proteins to the membrane context
T2 - A case study of phosphatidylserine and the TIM proteins
AU - Kerr, Daniel
AU - Tietjen, Gregory T.
AU - Gong, Zhiliang
AU - Tajkhorshid, Emad
AU - Adams, Erin J.
AU - Lee, Ka Yee C.
N1 - Funding Information:
This work was supported by the National Science Foundation (NSF) through grant No. MCB-1413613 (to K.Y.C.L.) and through resources provided by the Computation Institute and the Biological Sciences Division of the University of Chicago and Argonne National Laboratory , under National Institutes of Health (NIH) grant No. 1S10OD018495-01 . Additional National Institutes of Health (NIH) support was provided under grants No. R01-GM101048 , U54-GM087519 , and R01-AI073922 (to E.J.A.), U54-GM087519 , and P41-GM104601 (to E.T.) and Blue Waters and XSEDE compute resources (grant TG-MCA06N060 to E.T.). D.K. acknowledges the support of the National Institutes of Health (NIH) MCB training grant ( T32 GM007183 ). This work was partially supported by the University of Chicago Materials Research Science and Engineering Center, funded by the National Science Foundation (NSF) under award No. DMR- 1420709 .
Funding Information:
This work was supported by the National Science Foundation (NSF) through grant No. MCB-1413613 (to K.Y.C.L.) and through resources provided by the Computation Institute and the Biological Sciences Division of the University of Chicago and Argonne National Laboratory, under National Institutes of Health (NIH) grant No. 1S10OD018495-01. Additional National Institutes of Health (NIH) support was provided under grants No. R01-GM101048, U54-GM087519, and R01-AI073922 (to E.J.A.), U54-GM087519, and P41-GM104601 (to E.T.) and Blue Waters and XSEDE compute resources (grant TG-MCA06N060 to E.T.). D.K. acknowledges the support of the National Institutes of Health (NIH) MCB training grant (T32 GM007183). This work was partially supported by the University of Chicago Materials Research Science and Engineering Center, funded by the National Science Foundation (NSF) under award No. DMR-1420709.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/10
Y1 - 2018/10
N2 - There is a diverse class of peripheral membrane-binding proteins that specifically bind phosphatidylserine (PS), a lipid that signals apoptosis or cell fusion depending on the membrane context of its presentation. PS-receptors are specialized for particular PS-presenting pathways, indicating that they might be sensitive to the membrane context. In this review, we describe a combination of thermodynamic, structural, and computational techniques that can be used to investigate the mechanisms underlying this sensitivity. As an example, we focus on three PS-receptors of the T-cell Immunoglobulin and Mucin containing (TIM) protein family, which we have previously shown to differ in their sensitivity to PS surface density.
AB - There is a diverse class of peripheral membrane-binding proteins that specifically bind phosphatidylserine (PS), a lipid that signals apoptosis or cell fusion depending on the membrane context of its presentation. PS-receptors are specialized for particular PS-presenting pathways, indicating that they might be sensitive to the membrane context. In this review, we describe a combination of thermodynamic, structural, and computational techniques that can be used to investigate the mechanisms underlying this sensitivity. As an example, we focus on three PS-receptors of the T-cell Immunoglobulin and Mucin containing (TIM) protein family, which we have previously shown to differ in their sensitivity to PS surface density.
KW - Membrane composition sensitivity
KW - PS recognition
KW - Peripheral membrane proteins
KW - Phosphatidylserine
KW - TIM protein family
UR - http://www.scopus.com/inward/record.url?scp=85049323338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049323338&partnerID=8YFLogxK
U2 - 10.1016/j.bbamem.2018.06.010
DO - 10.1016/j.bbamem.2018.06.010
M3 - Review article
C2 - 29920237
AN - SCOPUS:85049323338
SN - 0005-2736
VL - 1860
SP - 2126
EP - 2133
JO - Biochimica et Biophysica Acta - Biomembranes
JF - Biochimica et Biophysica Acta - Biomembranes
IS - 10
ER -