Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins

Daniel Kerr, Gregory T. Tietjen, Zhiliang Gong, Emad Tajkhorshid, Erin J. Adams, Ka Yee C. Lee

Research output: Contribution to journalReview article

Abstract

There is a diverse class of peripheral membrane-binding proteins that specifically bind phosphatidylserine (PS), a lipid that signals apoptosis or cell fusion depending on the membrane context of its presentation. PS-receptors are specialized for particular PS-presenting pathways, indicating that they might be sensitive to the membrane context. In this review, we describe a combination of thermodynamic, structural, and computational techniques that can be used to investigate the mechanisms underlying this sensitivity. As an example, we focus on three PS-receptors of the T-cell Immunoglobulin and Mucin containing (TIM) protein family, which we have previously shown to differ in their sensitivity to PS surface density.

Original languageEnglish (US)
Pages (from-to)2126-2133
Number of pages8
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1860
Issue number10
DOIs
StatePublished - Oct 2018

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Keywords

  • Membrane composition sensitivity
  • PS recognition
  • Peripheral membrane proteins
  • Phosphatidylserine
  • TIM protein family

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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