Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping

Yun Sheng Chen, Wolfgang Frey, Charles Walker, Salavat Aglyamov, Stanislav Emelianov

Research output: Contribution to journalArticlepeer-review

Abstract

Photoacoustic imaging can be used to guide and validate the therapeutic outcome of nanoparticle-mediated photothermal therapy through its ability to visualize the delivery of nanoparticle contrast agents, image the temperature distribution inside living tissue, and confirm tissue coagulation. In this image-guided process, temperature mapping plays a critical role for thermal dosage control. Therefore, developing a sensitive and accurate photoacoustic technique to quantitatively measure the temperature distribution during thermal therapy is essential. In this study, we investigated and demonstrated that silica-coated gold nanorods, can provide a multi-fold improvement in sensitivity of the photoacoustic temperature mapping compared to gold nanorods without silica coating, and serve as a nanothermal sensor to accurately and quantitatively visualize temperature distributions during photothermal therapy.

Original languageEnglish (US)
Pages (from-to)534-542
Number of pages9
JournalJournal of Biophotonics
Volume6
Issue number6-7
DOIs
StatePublished - Jun 2013
Externally publishedYes

Keywords

  • Photoacoustics
  • Silica-coated gold nanorods
  • Temperature mapping
  • Temperature sensor

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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