Sensitive biological detection with a soluble and stable polymeric paramagnetic nanocluster

Benjamin Kim, Anne H. Schmieder, Allen J. Stacy, Todd A. Williams, Dipanjan Pan

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the design, synthesis, and biological characterization of manganese oxocluster-based "single molecule magnets (SMMs)". We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their property loss. Concentrating thousands of Mn-clusters per micelle provided a high ionic and per-particle relaxivity allowing sensitive MR imaging in vivo. This reports one of the earliest examples of in vivo imaging of a rationally designed polymeric micelle that features SMM.

Original languageEnglish (US)
Pages (from-to)10377-10380
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number25
DOIs
StatePublished - Jun 27 2012

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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