Abstract
The invention provides methods and compositions for detecting binding or unbinding of a molecule to a substrate. The molecule comprises a luminophore and the substrate comprises a semiconductor which acts as a luminescence quencher to provide distance-dependent quenching of the luminophore. Binding or unbinding of the molecule, which may be covalent or noncovalent, is detected as a decrease or increase, respectively, of the detectable luminescence of the luminophore.
| Original language | English (US) |
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| U.S. patent number | 6667179 |
| Filing date | 10/28/99 |
| State | Published - Dec 23 2003 |