Self-organization of nucleic acids in lipid constructs

Minjee Kang, Hojun Kim, Cecilia Leal

Research output: Contribution to journalReview article

Abstract

Lipids and nucleic acids (NAs) can hierarchically self-organize into a variety of nanostructures of increasingly complex geometries such as the 1D lamellar, 2D hexagonal, and 3D bicontinuous cubic phases. The diversity and complexity of those lipid–NA assemblies are interesting from a fundamental perspective as well as being relevant to the performance in gene delivery and gene silencing applications. The finding that not only the chemical make of the lipid–NA constructs, but their actual supramolecular organization, affects their gene transfection and silencing efficiencies has inspired physicists, chemists, and engineers to this field of research. At the moment it remains an open question how exactly the different lipid–NA structures interact with cells and organelles in order to output an optimal response. This article reviews our current understanding of the structures of different lipid–NA complexes and the corresponding cellular interaction mechanisms. The recent advances in designing optimal lipid–based NA carriers will be introduced with an emphasis on the structure–function relations.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
Volume26
DOIs
StatePublished - Dec 1 2016

Fingerprint

Nucleic acids
nucleic acids
genes
Nucleic Acids
Lipids
lipids
Genes
organelles
assemblies
engineers
Nanostructures
delivery
moments
Engineers
acids
Geometry
output
geometry
cells
interactions

Keywords

  • Gene delivery
  • Lipid–DNA
  • Lipid–siRNA
  • Self-assembly

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry

Cite this

Self-organization of nucleic acids in lipid constructs. / Kang, Minjee; Kim, Hojun; Leal, Cecilia.

In: Current Opinion in Colloid and Interface Science, Vol. 26, 01.12.2016, p. 58-65.

Research output: Contribution to journalReview article

@article{ee4c0f35414e4ebc80cdd07732bad232,
title = "Self-organization of nucleic acids in lipid constructs",
abstract = "Lipids and nucleic acids (NAs) can hierarchically self-organize into a variety of nanostructures of increasingly complex geometries such as the 1D lamellar, 2D hexagonal, and 3D bicontinuous cubic phases. The diversity and complexity of those lipid–NA assemblies are interesting from a fundamental perspective as well as being relevant to the performance in gene delivery and gene silencing applications. The finding that not only the chemical make of the lipid–NA constructs, but their actual supramolecular organization, affects their gene transfection and silencing efficiencies has inspired physicists, chemists, and engineers to this field of research. At the moment it remains an open question how exactly the different lipid–NA structures interact with cells and organelles in order to output an optimal response. This article reviews our current understanding of the structures of different lipid–NA complexes and the corresponding cellular interaction mechanisms. The recent advances in designing optimal lipid–based NA carriers will be introduced with an emphasis on the structure–function relations.",
keywords = "Gene delivery, Lipid–DNA, Lipid–siRNA, Self-assembly",
author = "Minjee Kang and Hojun Kim and Cecilia Leal",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.cocis.2016.09.006",
language = "English (US)",
volume = "26",
pages = "58--65",
journal = "Current Opinion in Colloid and Interface Science",
issn = "1359-0294",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Self-organization of nucleic acids in lipid constructs

AU - Kang, Minjee

AU - Kim, Hojun

AU - Leal, Cecilia

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Lipids and nucleic acids (NAs) can hierarchically self-organize into a variety of nanostructures of increasingly complex geometries such as the 1D lamellar, 2D hexagonal, and 3D bicontinuous cubic phases. The diversity and complexity of those lipid–NA assemblies are interesting from a fundamental perspective as well as being relevant to the performance in gene delivery and gene silencing applications. The finding that not only the chemical make of the lipid–NA constructs, but their actual supramolecular organization, affects their gene transfection and silencing efficiencies has inspired physicists, chemists, and engineers to this field of research. At the moment it remains an open question how exactly the different lipid–NA structures interact with cells and organelles in order to output an optimal response. This article reviews our current understanding of the structures of different lipid–NA complexes and the corresponding cellular interaction mechanisms. The recent advances in designing optimal lipid–based NA carriers will be introduced with an emphasis on the structure–function relations.

AB - Lipids and nucleic acids (NAs) can hierarchically self-organize into a variety of nanostructures of increasingly complex geometries such as the 1D lamellar, 2D hexagonal, and 3D bicontinuous cubic phases. The diversity and complexity of those lipid–NA assemblies are interesting from a fundamental perspective as well as being relevant to the performance in gene delivery and gene silencing applications. The finding that not only the chemical make of the lipid–NA constructs, but their actual supramolecular organization, affects their gene transfection and silencing efficiencies has inspired physicists, chemists, and engineers to this field of research. At the moment it remains an open question how exactly the different lipid–NA structures interact with cells and organelles in order to output an optimal response. This article reviews our current understanding of the structures of different lipid–NA complexes and the corresponding cellular interaction mechanisms. The recent advances in designing optimal lipid–based NA carriers will be introduced with an emphasis on the structure–function relations.

KW - Gene delivery

KW - Lipid–DNA

KW - Lipid–siRNA

KW - Self-assembly

UR - http://www.scopus.com/inward/record.url?scp=84991222543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991222543&partnerID=8YFLogxK

U2 - 10.1016/j.cocis.2016.09.006

DO - 10.1016/j.cocis.2016.09.006

M3 - Review article

AN - SCOPUS:84991222543

VL - 26

SP - 58

EP - 65

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

SN - 1359-0294

ER -