Self-navigated low-rank MRI for MPIO-labeled immune cell imaging of the heart

Anthony G. Christodoulou, Yijen L. Wu, T. Kevin Hitchens, Chien Ho, Zhi Pei Liang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Super-paramagnetic iron oxide (SPIO) particles can magnetically label immune cells in circulation; the accumulation of labeled cells can then be detected by magnetic resonance imaging (MRI). This has enormous potential for imaging inflammatory responses in the heart, but it has been difficult to do in vivo using conventional free-breathing, ungated cardiac imaging. Subspace imaging with temporal navigation and sparse sampling of (k, t)-space has previously been used to accelerate several cardiac imaging applications, conventionally alternating between acquiring navigator data and sparse data every other TR. Here we describe a more efficient self-navigated pulse sequence to acquire both navigator and sparse (k, t)-space data in the space of a single TR, doubling imaging speed to approach 100 frames per second (fps). We show the feasibility of using the resulting method to assess myocardial inflammation in a pre-clinical rodent ischemic reperfusion injury (IRI) model using micron-sized paramagnetic iron oxide (MPIO) particles to label immune cells in situ.

Original languageEnglish (US)
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1529-1532
Number of pages4
ISBN (Electronic)9781424479290
DOIs
StatePublished - Nov 2 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Publication series

Name2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
CountryUnited States
CityChicago
Period8/26/148/30/14

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering
  • Medicine(all)

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    Christodoulou, A. G., Wu, Y. L., Hitchens, T. K., Ho, C., & Liang, Z. P. (2014). Self-navigated low-rank MRI for MPIO-labeled immune cell imaging of the heart. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 1529-1532). [6943893] (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6943893