Self-Assembly of Repetitive Segment and Random Segment Polymer Architectures

Hao Yu, Falon C. Kalutantirige, Lehan Yao, Charles M. Schroeder, Qian Chen, Jeffrey S. Moore

Research output: Contribution to journalArticlepeer-review


Recent advances in chemical synthesis have created new methodologies for synthesizing sequence-controlled synthetic polymers, but rational design of monomer sequence for desired properties remains challenging. In this work, we synthesize periodic polymers with repetitive segments using a sequence-controlled ring-opening metathesis polymerization (ROMP) method, which draws inspiration from proteins containing repetitive sequence motifs. The repetitive segment architecture is shown to dramatically affect the self-assembly behavior of these materials. Our results show that polymers with identical repetitive sequences assemble into uniform spherical nanoparticles after thermal annealing, whereas copolymers with random placement of segments with different sequences exhibit disordered assemblies without a well-defined morphology. Overall, these results bring a new understanding to the role of periodic repetitive sequences in polymer assembly.

Original languageEnglish (US)
Pages (from-to)1366-1372
Number of pages7
JournalACS Macro Letters
Issue number12
StatePublished - Dec 20 2022

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Organic Chemistry


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