Self-assembly of micro- and nano-scale particles using bio-inspired events

H. McNally, M. Pingle, S. W. Lee, D. Guo, D. E. Bergstrom, R. Bashir

Research output: Contribution to journalArticlepeer-review


High sensitivity chemical and biological detection techniques and the development of future electronic systems can greatly benefit from self-assembly processes and techniques. We have approached this challenge using biologically inspired events such as the hybridization of single (ss)- to double-stranded (ds) DNA and the strong affinity between the protein avidin and its associated Vitamin, biotin. Using these molecules, micro-scale polystyrene beads and nano-scale gold particles were assembled with high efficiency on gold patterns and the procedures used for these processes were optimized. The DNA and avidin-biotin complex was also used to demonstrate the attachment of micro-scale silicon islands to each other in a fluid. This work also provides insight into the techniques for the self-assembly of heterogeneous materials.

Original languageEnglish (US)
Pages (from-to)109-119
Number of pages11
JournalApplied Surface Science
Issue number1-4
StatePublished - Jul 6 2003
Externally publishedYes


  • Bio-inspired self-assembly
  • Heterogeneous integration
  • Nanoparticles

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Condensed Matter Physics


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