Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents: Organic Radical-Functionalized Diblock Copolymers

Julian M.W. Chan; Rudy J. Wojtecki; Haritz Sardon; Ashlynn L.Z. Lee; Cartney E. Smith; Artem Shkumatov; Shujun Gao; Hyunjoon Kong; Yi Yan Yang; James L. Hedrick

doi:10.1021/acsmacrolett.6b00924

Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents: Organic Radical-Functionalized Diblock Copolymers

Julian M.W. Chan, Rudy J. Wojtecki, Haritz Sardon, Ashlynn L.Z. Lee, Cartney E. Smith, Artem Shkumatov, Shujun Gao, Hyunjoon Kong, Yi Yan Yang, James L. Hedrick

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Abstract

We report the design, synthesis, and evaluation of biodegradable amphiphilic poly(ethylene glycol)-b-polycarbonate-based diblock copolymers containing pendant persistent organic radicals (e.g., PROXYL). These paramagnetic radical-functionalized polymers self-assemble into micellar nanoparticles in aqueous media, which preferentially accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect. Through T₁ relaxation NMR studies, as well as magnetic resonance imaging (MRI) studies on mice, we show that these nanomaterials are effective as metal-free, biodegradable MRI contrast agents. We also demonstrate anticancer drugs can be readily loaded into the nanoparticles, conferring therapeutic delivery properties in addition to their imaging properties making these materials potential theranostic agents in the treatment of cancer.

Original language	English (US)
Pages (from-to)	176-180
Number of pages	5
Journal	ACS Macro Letters
Volume	6
Issue number	2
DOIs	https://doi.org/10.1021/acsmacrolett.6b00924
State	Published - Feb 21 2017

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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10.1021/acsmacrolett.6b00924

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title = "Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents: Organic Radical-Functionalized Diblock Copolymers",

abstract = "We report the design, synthesis, and evaluation of biodegradable amphiphilic poly(ethylene glycol)-b-polycarbonate-based diblock copolymers containing pendant persistent organic radicals (e.g., PROXYL). These paramagnetic radical-functionalized polymers self-assemble into micellar nanoparticles in aqueous media, which preferentially accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect. Through T1 relaxation NMR studies, as well as magnetic resonance imaging (MRI) studies on mice, we show that these nanomaterials are effective as metal-free, biodegradable MRI contrast agents. We also demonstrate anticancer drugs can be readily loaded into the nanoparticles, conferring therapeutic delivery properties in addition to their imaging properties making these materials potential theranostic agents in the treatment of cancer.",

author = "Chan, {Julian M.W.} and Wojtecki, {Rudy J.} and Haritz Sardon and Lee, {Ashlynn L.Z.} and Smith, {Cartney E.} and Artem Shkumatov and Shujun Gao and Hyunjoon Kong and Yang, {Yi Yan} and Hedrick, {James L.}",

note = "Funding Information: This study was supported by IBM Almaden Research Center, the Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore) National Institutes of Health (1R01 HL109192 to H.J.K.) and Chemistry Biology Interface Training Grant 5T32-GM070421 to C.E.S.). Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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doi = "10.1021/acsmacrolett.6b00924",

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T1 - Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents

T2 - Organic Radical-Functionalized Diblock Copolymers

AU - Chan, Julian M.W.

AU - Wojtecki, Rudy J.

AU - Sardon, Haritz

AU - Lee, Ashlynn L.Z.

AU - Smith, Cartney E.

AU - Shkumatov, Artem

AU - Gao, Shujun

AU - Kong, Hyunjoon

AU - Yang, Yi Yan

AU - Hedrick, James L.

N1 - Funding Information: This study was supported by IBM Almaden Research Center, the Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore) National Institutes of Health (1R01 HL109192 to H.J.K.) and Chemistry Biology Interface Training Grant 5T32-GM070421 to C.E.S.). Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/2/21

Y1 - 2017/2/21

N2 - We report the design, synthesis, and evaluation of biodegradable amphiphilic poly(ethylene glycol)-b-polycarbonate-based diblock copolymers containing pendant persistent organic radicals (e.g., PROXYL). These paramagnetic radical-functionalized polymers self-assemble into micellar nanoparticles in aqueous media, which preferentially accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect. Through T1 relaxation NMR studies, as well as magnetic resonance imaging (MRI) studies on mice, we show that these nanomaterials are effective as metal-free, biodegradable MRI contrast agents. We also demonstrate anticancer drugs can be readily loaded into the nanoparticles, conferring therapeutic delivery properties in addition to their imaging properties making these materials potential theranostic agents in the treatment of cancer.

AB - We report the design, synthesis, and evaluation of biodegradable amphiphilic poly(ethylene glycol)-b-polycarbonate-based diblock copolymers containing pendant persistent organic radicals (e.g., PROXYL). These paramagnetic radical-functionalized polymers self-assemble into micellar nanoparticles in aqueous media, which preferentially accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect. Through T1 relaxation NMR studies, as well as magnetic resonance imaging (MRI) studies on mice, we show that these nanomaterials are effective as metal-free, biodegradable MRI contrast agents. We also demonstrate anticancer drugs can be readily loaded into the nanoparticles, conferring therapeutic delivery properties in addition to their imaging properties making these materials potential theranostic agents in the treatment of cancer.

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Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents: Organic Radical-Functionalized Diblock Copolymers

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