Abstract

Mineralized biological tissues, whose behavior can range from rigid to compliant, are an essential component of vertebrates and invertebrates. Little is known about how the behavior of mineralized yet compliant tissues can be tuned by the degree of mineralization. In this work, a synthesis route to tune the structure and mechanical response of agarose gels via ionic crosslinking and mineralization has been developed. A combination of experimental techniques demonstrates that crosslinking via cooperative hydrogen bonding in agarose gels is disturbed by calcium ions, but they promote ionic crosslinking that modifies the agarose network. Further, it is shown that the rearrangement of the hydrogel network helps to accommodate precipitated minerals into the network -in other words, the hydrogel self-adapts to the precipitated mineral- while maintaining the viscoelastic behavior of the hydrogel, despite the reinforcement caused by mineralization. This work not only provides a synthesis route to design biologically inspired soft composites, but also helps to understand the change of properties that biomineralization can cause to biological tissues, organisms and biofilms.

Original languageEnglish (US)
Pages (from-to)5469-5480
Number of pages12
JournalSoft Matter
Volume13
Issue number32
DOIs
StatePublished - Jan 1 2017

Fingerprint

Hydrogels
Hydrogel
crosslinking
Crosslinking
Sepharose
Tissue
Minerals
Gels
routes
minerals
gels
invertebrates
Biomineralization
vertebrates
biofilms
Biofilms
synthesis
reinforcement
organisms
calcium

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Self-adaptive hydrogels to mineralization. / Shoaib, Tooba; Carmichael, Ariel; Corman, R. E.; Shen, Yun; Nguyen, Thanh Huong; Ewoldt, Randy H; Espinosa Marzal, Rosa Maria.

In: Soft Matter, Vol. 13, No. 32, 01.01.2017, p. 5469-5480.

Research output: Contribution to journalArticle

Shoaib, T, Carmichael, A, Corman, RE, Shen, Y, Nguyen, TH, Ewoldt, RH & Espinosa Marzal, RM 2017, 'Self-adaptive hydrogels to mineralization', Soft Matter, vol. 13, no. 32, pp. 5469-5480. https://doi.org/10.1039/c7sm01058c
Shoaib T, Carmichael A, Corman RE, Shen Y, Nguyen TH, Ewoldt RH et al. Self-adaptive hydrogels to mineralization. Soft Matter. 2017 Jan 1;13(32):5469-5480. https://doi.org/10.1039/c7sm01058c
Shoaib, Tooba ; Carmichael, Ariel ; Corman, R. E. ; Shen, Yun ; Nguyen, Thanh Huong ; Ewoldt, Randy H ; Espinosa Marzal, Rosa Maria. / Self-adaptive hydrogels to mineralization. In: Soft Matter. 2017 ; Vol. 13, No. 32. pp. 5469-5480.
@article{aae7d57f300e42f9a5ad6c08c1dd9ef8,
title = "Self-adaptive hydrogels to mineralization",
abstract = "Mineralized biological tissues, whose behavior can range from rigid to compliant, are an essential component of vertebrates and invertebrates. Little is known about how the behavior of mineralized yet compliant tissues can be tuned by the degree of mineralization. In this work, a synthesis route to tune the structure and mechanical response of agarose gels via ionic crosslinking and mineralization has been developed. A combination of experimental techniques demonstrates that crosslinking via cooperative hydrogen bonding in agarose gels is disturbed by calcium ions, but they promote ionic crosslinking that modifies the agarose network. Further, it is shown that the rearrangement of the hydrogel network helps to accommodate precipitated minerals into the network -in other words, the hydrogel self-adapts to the precipitated mineral- while maintaining the viscoelastic behavior of the hydrogel, despite the reinforcement caused by mineralization. This work not only provides a synthesis route to design biologically inspired soft composites, but also helps to understand the change of properties that biomineralization can cause to biological tissues, organisms and biofilms.",
author = "Tooba Shoaib and Ariel Carmichael and Corman, {R. E.} and Yun Shen and Nguyen, {Thanh Huong} and Ewoldt, {Randy H} and {Espinosa Marzal}, {Rosa Maria}",
year = "2017",
month = "1",
day = "1",
doi = "10.1039/c7sm01058c",
language = "English (US)",
volume = "13",
pages = "5469--5480",
journal = "Soft Matter",
issn = "1744-683X",
publisher = "Royal Society of Chemistry",
number = "32",

}

TY - JOUR

T1 - Self-adaptive hydrogels to mineralization

AU - Shoaib, Tooba

AU - Carmichael, Ariel

AU - Corman, R. E.

AU - Shen, Yun

AU - Nguyen, Thanh Huong

AU - Ewoldt, Randy H

AU - Espinosa Marzal, Rosa Maria

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Mineralized biological tissues, whose behavior can range from rigid to compliant, are an essential component of vertebrates and invertebrates. Little is known about how the behavior of mineralized yet compliant tissues can be tuned by the degree of mineralization. In this work, a synthesis route to tune the structure and mechanical response of agarose gels via ionic crosslinking and mineralization has been developed. A combination of experimental techniques demonstrates that crosslinking via cooperative hydrogen bonding in agarose gels is disturbed by calcium ions, but they promote ionic crosslinking that modifies the agarose network. Further, it is shown that the rearrangement of the hydrogel network helps to accommodate precipitated minerals into the network -in other words, the hydrogel self-adapts to the precipitated mineral- while maintaining the viscoelastic behavior of the hydrogel, despite the reinforcement caused by mineralization. This work not only provides a synthesis route to design biologically inspired soft composites, but also helps to understand the change of properties that biomineralization can cause to biological tissues, organisms and biofilms.

AB - Mineralized biological tissues, whose behavior can range from rigid to compliant, are an essential component of vertebrates and invertebrates. Little is known about how the behavior of mineralized yet compliant tissues can be tuned by the degree of mineralization. In this work, a synthesis route to tune the structure and mechanical response of agarose gels via ionic crosslinking and mineralization has been developed. A combination of experimental techniques demonstrates that crosslinking via cooperative hydrogen bonding in agarose gels is disturbed by calcium ions, but they promote ionic crosslinking that modifies the agarose network. Further, it is shown that the rearrangement of the hydrogel network helps to accommodate precipitated minerals into the network -in other words, the hydrogel self-adapts to the precipitated mineral- while maintaining the viscoelastic behavior of the hydrogel, despite the reinforcement caused by mineralization. This work not only provides a synthesis route to design biologically inspired soft composites, but also helps to understand the change of properties that biomineralization can cause to biological tissues, organisms and biofilms.

UR - http://www.scopus.com/inward/record.url?scp=85027469100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027469100&partnerID=8YFLogxK

U2 - 10.1039/c7sm01058c

DO - 10.1039/c7sm01058c

M3 - Article

VL - 13

SP - 5469

EP - 5480

JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 32

ER -