Selenocysteine derivatives for chemoselective ligations

Matt D. Gieselman; Yantao Zhu; Hao Zhou; Danica Galonic; Wilfred A. Van der Donk

doi:10.1002/1439-7633(20020802)3:8<709::AID-CBIC709>3.0.CO;2-8

Selenocysteine derivatives for chemoselective ligations

Matt D. Gieselman, Yantao Zhu, Hao Zhou, Danica Galonic, Wilfred A. Van der Donk

Research output: Contribution to journal › Article › peer-review

Abstract

Selenium variation on a cysteine theme: Selenocysteine (Sec) has been employed in a number of chemoselective ligations. Sec can be used for native chemical and expressed protein ligation, and Se-alkylated Sec-peptides are versatile precursors for dehydropeptides. The latter can be used for chemoselective and convergent preparation of peptide conjugates (see scheme).

Original language	English (US)
Pages (from-to)	709-716
Number of pages	8
Journal	ChemBioChem
Volume	3
Issue number	8
DOIs	https://doi.org/10.1002/1439-7633(20020802)3:8<709::AID-CBIC709>3.0.CO;2-8
State	Published - 2002

Keywords

Enzymes
Glycopeptides
Ligations
Protein engineering
Selenium

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

Online availability

10.1002/1439-7633(20020802)3:8<709::AID-CBIC709>3.0.CO;2-8

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AU - Zhu, Yantao

AU - Zhou, Hao

AU - Galonic, Danica

AU - Van der Donk, Wilfred A.

PY - 2002

Y1 - 2002

N2 - Selenium variation on a cysteine theme: Selenocysteine (Sec) has been employed in a number of chemoselective ligations. Sec can be used for native chemical and expressed protein ligation, and Se-alkylated Sec-peptides are versatile precursors for dehydropeptides. The latter can be used for chemoselective and convergent preparation of peptide conjugates (see scheme).

AB - Selenium variation on a cysteine theme: Selenocysteine (Sec) has been employed in a number of chemoselective ligations. Sec can be used for native chemical and expressed protein ligation, and Se-alkylated Sec-peptides are versatile precursors for dehydropeptides. The latter can be used for chemoselective and convergent preparation of peptide conjugates (see scheme).

KW - Enzymes

KW - Glycopeptides

KW - Ligations

KW - Protein engineering

KW - Selenium

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ER -

Selenocysteine derivatives for chemoselective ligations

Abstract

Keywords

ASJC Scopus subject areas

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