Selenocysteine derivatives for chemoselective ligations

Matt D. Gieselman, Yantao Zhu, Hao Zhou, Danica Galonic, Wilfred A. Van der Donk

Research output: Contribution to journalArticlepeer-review


Selenium variation on a cysteine theme: Selenocysteine (Sec) has been employed in a number of chemoselective ligations. Sec can be used for native chemical and expressed protein ligation, and Se-alkylated Sec-peptides are versatile precursors for dehydropeptides. The latter can be used for chemoselective and convergent preparation of peptide conjugates (see scheme).

Original languageEnglish (US)
Pages (from-to)709-716
Number of pages8
Issue number8
StatePublished - 2002


  • Enzymes
  • Glycopeptides
  • Ligations
  • Protein engineering
  • Selenium

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry


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