Selective targeting of phosphodiesterases to develop potent antiparasitic drugs

Shahbaz M. Khan; Md Mukthar Mia; William H. Witola

doi:10.1016/j.pt.2024.11.001

Selective targeting of phosphodiesterases to develop potent antiparasitic drugs

Shahbaz M. Khan, Md Mukthar Mia, William H. Witola

Pathobiology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently, Ajiboye et al. reported validation of Cryptosporidium PDE1 (CpPDE1) as a viable drug target and identified optimized pyrazolopyrimidines with selective activity against CpPDE1 over human PDEs and with potent anticryptosporidial efficacy.

Original language	English (US)
Pages (from-to)	1075-1076
Number of pages	2
Journal	Trends in Parasitology
Volume	40
Issue number	12
DOIs	https://doi.org/10.1016/j.pt.2024.11.001
State	Published - Dec 2024

Keywords

Cryptosporidium
cyclic-nucleotides
drug-target
phosphodiesterases
pyrazolopyrimidines
selective-inhibition

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Online availability

10.1016/j.pt.2024.11.001

Library availability

Discover UIUC Full Text

Cite this

@article{3c66781ce7924e31b1016ba08318480a,

title = "Selective targeting of phosphodiesterases to develop potent antiparasitic drugs",

abstract = "Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently, Ajiboye et al. reported validation of Cryptosporidium PDE1 (CpPDE1) as a viable drug target and identified optimized pyrazolopyrimidines with selective activity against CpPDE1 over human PDEs and with potent anticryptosporidial efficacy.",

keywords = "Cryptosporidium, cyclic-nucleotides, drug-target, phosphodiesterases, pyrazolopyrimidines, selective-inhibition",

author = "Khan, {Shahbaz M.} and Mia, {Md Mukthar} and Witola, {William H.}",

note = "This work was supported by USDA-NIFA-AFRI grant number 2022-67015-36347 to W.H.W.",

year = "2024",

month = dec,

doi = "10.1016/j.pt.2024.11.001",

language = "English (US)",

volume = "40",

pages = "1075--1076",

journal = "Trends in Parasitology",

issn = "1471-4922",

publisher = "Elsevier Ltd",

number = "12",

}

TY - JOUR

T1 - Selective targeting of phosphodiesterases to develop potent antiparasitic drugs

AU - Khan, Shahbaz M.

AU - Mia, Md Mukthar

AU - Witola, William H.

N1 - This work was supported by USDA-NIFA-AFRI grant number 2022-67015-36347 to W.H.W.

PY - 2024/12

Y1 - 2024/12

N2 - Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently, Ajiboye et al. reported validation of Cryptosporidium PDE1 (CpPDE1) as a viable drug target and identified optimized pyrazolopyrimidines with selective activity against CpPDE1 over human PDEs and with potent anticryptosporidial efficacy.

AB - Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently, Ajiboye et al. reported validation of Cryptosporidium PDE1 (CpPDE1) as a viable drug target and identified optimized pyrazolopyrimidines with selective activity against CpPDE1 over human PDEs and with potent anticryptosporidial efficacy.

KW - Cryptosporidium

KW - cyclic-nucleotides

KW - drug-target

KW - phosphodiesterases

KW - pyrazolopyrimidines

KW - selective-inhibition

UR - http://www.scopus.com/inward/record.url?scp=85209125477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85209125477&partnerID=8YFLogxK

U2 - 10.1016/j.pt.2024.11.001

DO - 10.1016/j.pt.2024.11.001

M3 - Short survey

C2 - 39550300

AN - SCOPUS:85209125477

SN - 1471-4922

VL - 40

SP - 1075

EP - 1076

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 12

ER -

Selective targeting of phosphodiesterases to develop potent antiparasitic drugs

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this